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https://hdl.handle.net/1822/29554| Título: | Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat |
| Autor(es): | Ansah, Osei B. Bourbia, Nora Gonçalves, Leonor Almeida, Armando Pertovaara, Antti |
| Palavras-chave: | Amygdal Aversive place-conditioning Descending pain modulation Emotional pain Mechanical pain sensibility Peripheral neuropathy Amygdala |
| Data: | 2010 |
| Editora: | Elsevier 1 |
| Revista: | Behavioural Brain Research |
| Resumo(s): | The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/29554 |
| DOI: | 10.1016/j.bbr.2010.01.021 |
| ISSN: | 0166-4328 |
| Versão da editora: | http://www.sciencedirect.com/science/article/pii/S0166432810000458 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| ansah o_behav brain res 2010.pdf | 749,4 kB | Adobe PDF | Ver/Abrir |
