Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/29733
Título: | Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors |
Autor(es): | Heinke, Thaís Espiríto Santo, Kleber Simões do Longatto Filho, Adhemar Stávale, João N. |
Palavras-chave: | Glioma Neovascularization Pathologic Immunohistochemistry |
Data: | Jan-2013 |
Revista: | Acta Cirúrgica Brasileira |
Resumo(s): | PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/29733 |
DOI: | 10.1590/S0102-86502013000100008 |
ISSN: | 0102-8650 1678-2674 |
Versão da editora: | http://www.scielo.br/scielo.php?script=sci_serial&pid=0102-8650&lng=en&nrm=iso |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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heinke thais_acta cirurg brasil 2013.pdf | 1,17 MB | Adobe PDF | Ver/Abrir |