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https://hdl.handle.net/1822/32986
Título: | Iron levels in the human brain: a post-morten study of anatomical region differences and age-related changes |
Autor(es): | Ramos, Patrícia Santos, Agostinho Pinto, Nair Rosas Mendes, Ricardo Magalhães, Teresa Almeida, Agostinho |
Palavras-chave: | Human brain Iron levels Post - mortem analysis Ageing Neurodegenerative diseases Post-mortem analysis |
Data: | 2014 |
Editora: | Elsevier 1 |
Revista: | Journal of Trace Elements in Medicine and Biology |
Resumo(s): | The link between brain iron homeostasis and neurodegenerative disease has been the subject of extensive research. There is increasing evidence of iron accumulation during ageing, and altered iron levels in some specific brain regions in neurodegenerative disease patients have been reported. Using graphite furnace atomic absorption spectrometry after microwave-assisted acid digestion of the samples, iron levels were determined in 14 different areas of the human brain [frontal cortex, superior and middle temporal, caudate nucleus, putamen, globus pallidus, cingulated gyrus, hippocampus, inferior parietal lobule, visual cortex of the occipital lobe, midbrain, pons (locus coeruleus), medulla and cerebellum (dentate nucleus)] of n=42 adult individuals (71±12 years old, range: 53-101 years old) with no known history or evidence of neurodegenerative, neurological or psychiatric disorders. It was found that the iron distribution in the adult human brain is quite heterogeneous. The highest levels were found in the putamen (mean±SD, range: 855±295µg/g, 304-1628µg/g) and globus pallidus (739±390µg/g, 225-1870µg/g), and the lowest levels were observed in the pons (98±43µg/g, 11-253µg/g) and medulla (56±25µg/g, 13-115µg/g). Globally, iron levels proved to be age-related. The positive correlation between iron levels and age was most significant in the basal ganglia (caudate nucleus, putamen and globus pallidus). Compared with the age-matched control group, altered iron levels were observed in specific brain areas of one Parkinson's disease patient (the basal ganglia) and two Alzheimer's disease patients (the hippocampus). |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/32986 |
DOI: | 10.1016/j.jtemb.2013.08.001 |
ISSN: | 0946-672X |
Versão da editora: | http://www.elsevier.com/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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ramos p_j trace elem med bio 2014 prep.pdf | 261,77 kB | Adobe PDF | Ver/Abrir |