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https://hdl.handle.net/1822/38303
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Campo DC | Valor | Idioma |
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dc.contributor.author | Oliveira, Sara M. | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Mano, J. F. | por |
dc.date.accessioned | 2015-11-19T12:53:48Z | - |
dc.date.issued | 2015-11 | - |
dc.date.submitted | 2015-01 | - |
dc.identifier.citation | Oliveira S. M., Reis R. L., Mano J. F. Towards the Design of 3D Multiscale Instructive Tissue Engineering Constructs: Current approaches and trends, Biotechnology Advances, Vol. 33, Issue 6 Part. 1, pp. i842–855, doi:10.1016/j.biotechadv.2015.05.007, 2015 | por |
dc.identifier.issn | 0734-9750 | por |
dc.identifier.uri | https://hdl.handle.net/1822/38303 | - |
dc.description.abstract | The design of 3D constructs with adequate properties to instruct and guide cells both in vitro and in vivo is one of the major focuses of tissue engineering. Successful tissue regeneration depends on the favorable crosstalk between the supporting structure, the cells and the host tissue so that a balanced matrix production and degradation is achieved. Herein, the major occurring events and players in normal and regenerative tissue are overviewed. These have been inspiring the selection or synthesis of instructive cues to include into the 3D constructs. We further highlight the importance of a multiscale perception of the range of features that can be included on the biomimetic structures. Lastly, we focus on the current and developing tissue-engineering approaches for the preparation of such 3D constructs: top-down, bottom-up and integrative. Bottom-up and integrative approaches present a higher potential for the design of tissue engineering devices with multiscale features and higher biochemichal control than top-down strategies, and are the main focus of this review. | por |
dc.description.sponsorship | The research leading to these results has received funding from the European Research Council grant agreement ERC-2012-ADG-20120216-321266 for the project ComplexiTE. Portuguese Foundation for Science and Technology is gratefully acknowledged for the fellowship of Sara M. Oliveira (SFRH/BD/70107/2010). | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/321266/EU | por |
dc.rights | openAccess | - |
dc.subject | Biomaterials | por |
dc.subject | Bottom-up | por |
dc.subject | Building-blocks | por |
dc.subject | Construct | por |
dc.subject | Instructive | por |
dc.subject | Integrative | por |
dc.subject | Multiscale | por |
dc.subject | Nano | por |
dc.subject | Nanobiomaterials | por |
dc.subject | Scaffolds | por |
dc.subject | Top-down | por |
dc.title | Towards the design of 3D multiscale instructive tissue engineering constructs: Current approaches and trends | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0734975015300069 | por |
dc.comments | http://www.3bs.uminho.pt/node/18446 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 842 | por |
oaire.citationEndPage | 855 | por |
oaire.citationIssue | 6 Part. 1 | por |
oaire.citationTitle | Biotechnology Advances | por |
oaire.citationVolume | 33 | por |
dc.date.updated | 2015-11-09T11:30:54Z | - |
dc.identifier.doi | 10.1016/j.biotechadv.2015.05.007 | por |
dc.identifier.pmid | 26025038 | por |
dc.subject.fos | Ciências Médicas::Biotecnologia Médica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Biotechnology Advances | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18446-Towards the design of 3D multiscale instructive tissue engineering constructs- Current approaches and trends.pdf | 2,09 MB | Adobe PDF | Ver/Abrir |