Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/39115
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Senhorães, Nádia | por |
dc.contributor.author | Proença, M. Fernanda R. P. | por |
dc.contributor.author | Dias, Alice | por |
dc.date.accessioned | 2015-12-21T19:15:47Z | - |
dc.date.issued | 2015-12-01 | - |
dc.identifier.uri | https://hdl.handle.net/1822/39115 | - |
dc.description.abstract | [Excerpt] Purine nucleobases are fundamental biochemicals in living organisms. They have been a valuable inspiration for drug design once they play several key roles in the cell.1 To the best of our knowledge, reported routes to 8-aminopurines are still scarce due to the difficulty in introducing amino groups in this position of the purine ring. Here we report a novel, inexpensive and facile synthetic method to generate N3,N6-disubstituted-6,8-diaminopurines. In our research group, a number of substituted purines have been obtained from a common imidazole precursor, the 5-amino-4-cyanoformimidoyl imidazole 1. Recently, a comprehensive study on the reactivity of imidazoles 1 with nucleophiles under acidic conditions led us to develop experimental methods to incorporate primary amines into the cyanoformimidoyl group.2 (...) | por |
dc.description.sponsorship | FCT (NMR portuguese network; PhD Grant SFRH/BD/73721/2010); FCT and FEDER-COMPETE-QREN-EU [Pest-C/QUI/UI0686/2011 (FCOMP-01-0124-FEDER-022716)]. | por |
dc.language.iso | eng | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F73721%2F2010/PT | por |
dc.relation | Pest-C/QUI/UI0686/2011 | por |
dc.rights | restrictedAccess | por |
dc.subject | Química Orgânica | por |
dc.title | A novel and efficient approach to new N3-substituted-6,8-diaminopurines | por |
dc.type | conferenceAbstract | - |
dc.peerreviewed | yes | por |
sdum.publicationstatus | published | por |
oaire.citationConferenceDate | 8 Maio 2015 | por |
sdum.event.type | congress | por |
oaire.citationTitle | 2nd Symposium on Medicinal Chemistry of the University of Minho | por |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
sdum.conferencePublication | 2nd Symposium on Medicinal Chemistry of the University of Minho | por |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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SQM_A novel and efficient approach to new N3-substituted-6,8-diaminopurines.pdf Acesso restrito! | 111,31 kB | Adobe PDF | Ver/Abrir |