Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/40108
Título: | IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages |
Autor(es): | Cruz, Andrea Ludovico, Paula Torrado, Egídio Gama, José B. Sousa, Jeremy Nicolas Carvalho Gaifem, Joana Appelberg, Rui Rodrigues, Fernando José dos Santos Cooper, Andrea M. Pedrosa, Jorge Saraiva, Margarida Castro, António G. |
Palavras-chave: | IL-17 p53 Apoptosis Mycobacteria Macrophages |
Data: | Set-2015 |
Editora: | Frontiers Media |
Revista: | Frontiers in Immunology |
Citação: | Cruz, A., Ludovico, P., et. al. (2015). IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages. Frontiers in immunology, 6. |
Resumo(s): | The fate of infected macrophages is a critical aspect of immunity to mycobacteria. By depriving the pathogen of its intracellular niche, apoptotic death of the infected macrophage has been shown to be an important mechanism to control bacterial growth. Here, we show that IL-17 inhibits apoptosis of Mycobacterium bovis BCG- or Mycobacterium tuberculosis-infected macrophages thus hampering their ability to control bacterial growth. Mechanistically, we show that IL-17 inhibits p53, and impacts on the intrinsic apoptotic pathway, by increasing the Bcl2 and decreasing Bax expression, decreasing cytochrome c release from the mitochondria, and inhibiting caspase-3 activation. The same effect of IL-17 was observed in infected macrophages upon blockade of p53 nuclear translocation. These results reveal a previously unappreciated role for the IL-17/p53 axis in the regulation of mycobacteria-induced apoptosis and can have important implications in a broad spectrum of diseases where apoptosis of the infected cell is an important host defense mechanism. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/40108 |
DOI: | 10.3389/fimmu.2015.00498 |
ISSN: | 1664-3224 |
Versão da editora: | http://journal.frontiersin.org/article/10.3389/fimmu.2015.00498/abstract |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
fimmu-06-00498.pdf | 1,08 MB | Adobe PDF | Ver/Abrir |