Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/40248
Título: | A novel small-caliber bacterial cellulose vascular prosthesis: production, characterization, and preliminary in vivo testing |
Autor(es): | Leitão, Alexandre F. Faria, Miguel A. Faustino, Augusto M. R. Moreira, Ricardo Mela, Petra Loureiro, Luís Silva, Ivone Gama, F. M. |
Palavras-chave: | Bacterial cellulose Biocompatibility Endothelialization Mechanical properties Surface roughness Vascular grafts |
Data: | 2016 |
Editora: | John Wiley and Sons |
Revista: | Macromolecular Bioscience |
Citação: | Leitão, A.; Faria, Miguel A.; Faustino, Augusto M. R.; Moreira, Ricardo; Mela, Petra; Loureiro, Luís; Silva, Ivone; Gama, F. M., A novel small-caliber bacterial cellulose vascular prosthesis: production, characterization, and preliminary in vivo testing. Macromolecular Bioscience, 16(16), 139-150, 2016 |
Resumo(s): | Vascular grafts are used to bypass damaged or diseased blood vessels. Bacterial cellulose (BC) has been studied for use as an off-the-shelf graft. Herein, we present a novel, cost-effective, method for the production of small caliber BC grafts with minimal processing or requirements. The morphology of the graft wall produced a tensile strength above that of native vessels, performing similarly to the current commercial alternatives. As a result of the production method, the luminal surface of the graft presents similar topography to that of native vessels. We have also studied the in vivo behavior of these BC graft in order to further demonstrate their viability. In these preliminary studies, 1 month patency was achieved, with the presence of neo-vessels and endothelial cells on the luminal surface of the graft. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/40248 |
DOI: | 10.1002/mabi.201500251 |
ISSN: | 1616-5187 |
e-ISSN: | 1616-5195 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_22383_1.pdf | 1,54 MB | Adobe PDF | Ver/Abrir |