Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/40282
Título: | Ki-67 expression in CRC lymph node metastasis does not predict survival |
Autor(es): | Martins, Sandra Amorim, Ricardo Mota, Sílvia Coelho Costa, Luís Pardal, Fernando Rodrigues, Mesquita Longatto Filho, Adhemar |
Data: | 2015 |
Editora: | Hindawi Publishing Corporation |
Revista: | Biomed Research International |
Citação: | Martins, S. F., Amorim, R., Mota, S. C., Costa, L., Pardal, F., Rodrigues, M., & Longatto-Filho, A. (2015). Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival. BioMed Research International, 2015. doi: 10.1155/2015/131685 |
Resumo(s): | Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumourassociated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained byKi-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/40282 |
DOI: | 10.1155/2015/131685 |
ISSN: | 2314-6133 |
Versão da editora: | http://www.hindawi.com/journals/bmri/aa/131685/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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bmri2015-131685.pdf | 3,46 MB | Adobe PDF | Ver/Abrir |