Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/40293
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Campo DC | Valor | Idioma |
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dc.contributor.author | Rebelo, Márcia A. | por |
dc.contributor.author | Chaud, Marco V. | por |
dc.contributor.author | Balcão, V. M. | por |
dc.contributor.author | Vila, Marta M. D. C. | por |
dc.contributor.author | Aranha, Norberto | por |
dc.contributor.author | Yoshida, Valquíria M. H. | por |
dc.contributor.author | Alves, Thaís F. | por |
dc.contributor.author | Oliveira Jr. , José M. | por |
dc.date.accessioned | 2016-02-15T14:43:20Z | - |
dc.date.available | 2016-02-15T14:43:20Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Rebelo, Márcia A.; Chaud, Marco V.; Balcão, V. M.; Vila, Marta M. D. C.; Aranha, Norberto; Yoshida, Valquíria M. H.; Alves, Thaís F.; Oliveira Jr, José M. De, Chitosan-based scaffolds for tissue regeneration: preparation and microstructure characterization. European Journal of Biomedical and Pharmaceutical Sciences, 3(1), 15-24, 2016 | por |
dc.identifier.issn | 2349-8870 | por |
dc.identifier.uri | https://hdl.handle.net/1822/40293 | - |
dc.description.abstract | Scaffolds are porous three-dimensional supports, designed to mimic the extracellular environment and remain temporarily integrated into the host tissue while stimulating, at the molecular level, specific cellular responses to each type of body tissues. The major goal of the research work entertained herein was to study the microstructure of scaffolds made from chitosan (Ch), blends of chitosan and sodium alginate (Ch/NaAlg), blends of chitosan, sodium alginate and calcium chloride (Ch/NaAlg/CaCl2) and blends of chitosan, sodium alginate and hydroxyapatite (Ch/NaAlg/HA). Scaffolds possessing ideal physicochemical properties facilitate cell proliferation and greatly increase the rate of recovery of a damaged organ tissue. Using CT three-dimensional images of the scaffolds, it was observed that all scaffolds had a porosity in the range 64%-92%, a radius of maximum pore occurrence in the range 95m-260m and a permeability in the range 1×10-10-18×10-10 m2. From the results obtained, the scaffolds based on Ch, Ch/NaAlg and Ch/NaAlg/CaCl2 would be most appropriate both for the growth of osteoid and for bone tissue regeneration, while the scaffold made with a blend of Ch/NaAlg/HA, by possessing larger pores size, might be used as a support for fibrovascular tissue. | por |
dc.description.sponsorship | Project funding by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, São Paulo, Brazil) (FAPESP Refs. No. 2012/21219-5, 2012/15651-4, 2013/03181-6, 2013/19300-4, and 2014/21122-0), is hereby gratefully acknowledged. This work received support from CNPq, National Council for Scientific and Technological Development – Brazil, in the form of Research Productivity (PQ) fellowships granted to Victor M. Balcão and Marco V. Chaud. | por |
dc.language.iso | eng | por |
dc.publisher | Ejbps | por |
dc.rights | openAccess | por |
dc.subject | Tissue regeneration | por |
dc.subject | Chitosan scaffolds | por |
dc.subject | Computed tomography | por |
dc.subject | Porosity | por |
dc.subject | Permeability | por |
dc.title | Chitosan-based scaffolds for tissue regeneration: preparation and microstructure characterization | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.ejbps.com/ | por |
dc.comments | CEB33789 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 15 | por |
oaire.citationEndPage | 24 | por |
oaire.citationIssue | 1 | por |
oaire.citationTitle | European Journal of Biomedical and Pharmaceutical Sciences | por |
oaire.citationVolume | 3 | por |
dc.date.updated | 2016-02-03T22:11:44Z | - |
dc.identifier.eissn | 2349-8870 | - |
sdum.journal | European Journal of Biomedical and Pharmaceutical Sciences | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_33789_1.pdf | 1,08 MB | Adobe PDF | Ver/Abrir |