Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/40312
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Campo DC | Valor | Idioma |
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dc.contributor.author | Silva, Joana M. | por |
dc.contributor.author | Caridade, S. G. | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Mano, J. F. | por |
dc.date.accessioned | 2016-02-15T15:58:19Z | - |
dc.date.issued | 2016 | - |
dc.date.submitted | 2015-10 | - |
dc.identifier.citation | Silva J. M., Caridade S. G., Reis R. L., Mano J. F. Polysaccharide-based freestanding multilayered membranes exhibiting reversible switchable properties, Soft Matter, doi:10.1039/C5SM02458G, 2016. | por |
dc.identifier.issn | 1744-683X | por |
dc.identifier.uri | https://hdl.handle.net/1822/40312 | - |
dc.description.abstract | The design of self-standing multilayered structures based on biopolymers has been attracting increasing interest due to their potential in the biomedical field. However, their use has been limited due to their gel-like properties. Herein, we report the combination of covalent and ionic cross-linking, using natural and non-cytotoxic cross-linkers, such as genipin and calcium chloride (CaCl2). Combining both cross-linking types the mechanical properties of the multilayers increased and the water uptake ability decreased. The ionic cross-linking of multilayered chitosan (CHI)â alginate (ALG) films led to freestanding membranes with multiple interesting properties, such as: improved mechanical strength, calcium-induced adhesion and shape memory ability. The use of CaCl2 also offered the possibility of reversibly switching all of these properties by simple immersion in a chelate solution. We attribute the switch-ability of the mechanical properties, shape memory ability and the propensity for induced-adhesion to the ionic cross-linking of the multilayers. These findings suggested the potential of the developed polysaccharide freestanding membranes in a plethora of research fields, including in biomedical and biotechnological fields. | por |
dc.description.sponsorship | Portuguese Foundation for Science and Technology (FCT) through the doctoral and Post-doctoral grants with the reference numbers SFRH/BD/81372/2011 (JMS) and SFRH/BPD/96797/2013 (SGC), respectively. This work was financially supported by Foundation for Science and Technology (FCT), by the project PTDC/FIS/115048/2009. The authors would also like to acknowledge the project novel smart and biomimetic materials for innovative regenerative medicine approaches (Ref. RL1 – ABMR – NORTE-01-0124-FEDER-000016) co-financed by North Portugal Regional Operational Programme (ON.2 – O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF). | por |
dc.language.iso | eng | por |
dc.publisher | Royal Society of Chemistry | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/115048/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | Biomaterials | por |
dc.subject | Calcium-induced adhesion | por |
dc.subject | Dynamic mechanical analysis | por |
dc.subject | Layer-by-layer | por |
dc.subject | Nanobiomaterials | por |
dc.subject | Shape-memory | por |
dc.title | Polysaccharide-based freestanding multilayered membranes exhibiting reversible switchable properties | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://pubs.rsc.org/en/content/articlelanding/2016/sm/c5sm02458g#!divAbstract | por |
dc.comments | http://www.3bs.uminho.pt/node/18638 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 1200 | por |
oaire.citationEndPage | 1209 | por |
oaire.citationIssue | 4 | por |
oaire.citationTitle | Soft Matter | por |
oaire.citationVolume | 12 | por |
dc.date.updated | 2016-02-01T09:50:19Z | - |
dc.identifier.doi | 10.1039/C5SM02458G | por |
dc.identifier.pmid | 26617221 | por |
dc.subject.fos | Engenharia e Tecnologia::Biotecnologia Industrial | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Soft Matter | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18638-Soft Matter.pdf Acesso restrito! | 3,08 MB | Adobe PDF | Ver/Abrir |