Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/43824
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Campo DC | Valor | Idioma |
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dc.contributor.author | Silva, Simone Santos | por |
dc.contributor.author | Oliveira, Nuno M. | por |
dc.contributor.author | Oliveira, Mariana Braga | por |
dc.contributor.author | Costa, Diana Soares da | por |
dc.contributor.author | Naskar, Deboki | por |
dc.contributor.author | Mano, J. F. | por |
dc.contributor.author | Kundu, S. C. | por |
dc.contributor.author | Reis, R. L. | por |
dc.date.accessioned | 2016-12-23T10:11:04Z | - |
dc.date.available | 2016-12-23T10:11:04Z | - |
dc.date.issued | 2016-01 | - |
dc.date.submitted | 2016-01 | - |
dc.identifier.citation | Silva S. S., Oliveira N. M., Oliveira M.B., Soares da Costa D., Naskar D., Mano J. F., Kundu S. C., Reis R. L. Fabrication and characterization of Eri silk fibers-based sponges for biomedical application, Acta Biomaterialia, Vol. 32, pp. 178-189, doi:10.1016/j.actbio.2016.01.003, 2016 | por |
dc.identifier.issn | 1742-7061 | por |
dc.identifier.uri | https://hdl.handle.net/1822/43824 | - |
dc.description.abstract | Cocoon-derived semi-domesticated Eri silk fibers still lack exploitation for tissue engineering applications due to their poor solubility using conventional methods. The present work explores the ability to process cocoon fibers of non-mulberry Eri silk (Samia/Philosamia ricini) into sponges through a green approach using ionic liquid (IL) â 1-buthyl-imidazolium acetate as a solvent. The formation of β-sheet structures during Eri silk/IL gelation was acquired by exposing the Eri silk/IL gels to a saturated atmosphere composed of two different solvents: (i) isopropanol/ethanol (physical stabilization) and (ii) genipin, a natural crosslinker, dissolved in ethanol (chemical crosslinking). The sponges were then obtained by freeze-drying. This approach promotes the formation of both stable and ordered non-crosslinked Eri silk fibroin matrices. Moreover, genipin-crosslinked silk fibroin sponges presenting high height recovery capacity after compression, high swelling degree and suitable mechanical properties for tissue engineering applications were produced. The incorporation of a model drug â ibuprofen â and the corresponding release study from the loaded sponges demonstrated the potential of using these matrices as effective drug delivery systems. The assessment of the biological performance of ATDC5 chondrocyte-like cells in contact with the developed sponges showed the promotion of cell adhesion and proliferation, as well as extracellular matrix production within two weeks of culture. Spongesâ intrinsic properties and biological findings open up their potential use for biomedical applications. | por |
dc.description.sponsorship | The authors SSS, DSC, MBO, NMO acknowledge financial support from Portuguese Foundation for Science and Technology – FCT (Grants SFRH/BPD/45307/2008, SFRH/BPD/85790/2012, SFRH/BD/71396/2010 and SFRH/BD/73172/2010, respectively), ‘‘Fundo Social Europeu” – FSE, and ‘‘Programa Diferencial de Potencial Humano POPH”. This work is also financially supported by the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n REGPOT-CT2012-316331-POLARIS and from Fundação para a Ciência e Tecnologia (FCT) through the project ENIGMA – PTDC/EQU-EPR/121491/2010. The laboratory work of SCK is supported by Department of Biotechnology and Indian Council of Medical Research, Govt of India. SCK and RLR acknowledge their short visits either Institutes. SCK is also grateful to 3B´ s Research Group- Biomaterials, Biodegradables and Biomimetics, University of Minho, Portugal for providing facilities during his short visit. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F45307%2F2008/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F85790%2F2012/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F71396%2F2010/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F73172%2F2010/PT | por |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/316331/EU | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/121491/PT | por |
dc.rights | openAccess | por |
dc.subject | Cartilage regeneration | por |
dc.subject | Eri | por |
dc.subject | Fibroin | por |
dc.subject | Genipin | por |
dc.subject | Ionic liquids | por |
dc.subject | Samia ricini | por |
dc.title | Fabrication and characterization of Eri silk fibers-based sponges for biomedical application | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S1742706116300034 | por |
dc.comments | http://3bs.uminho.pt/node/18651 | por |
sdum.publicationstatus | info:eu-repo/semantics/publishedVersion | por |
oaire.citationStartPage | 178 | por |
oaire.citationEndPage | 189 | por |
oaire.citationTitle | Acta Biomaterialia | por |
oaire.citationVolume | 32 | por |
dc.date.updated | 2016-12-14T15:14:12Z | - |
dc.identifier.doi | 10.1016/j.actbio.2016.01.003 | por |
dc.identifier.pmid | 26766632 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Acta Biomaterialia | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18651-Acta biomaterialia_Eri Silk .pdf | 1,85 MB | Adobe PDF | Ver/Abrir |