Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/49293
Título: | Permeation of model membranes by Peptaibolin mimetics bearing different α,α-dialkylglycines |
Autor(es): | Carvalho, Carina Martins Castro, Vânia Isabel Baptista Pereira-Lima, Sílvia M. M. A. Castanheira, Elisabete M. S. Costa, Susana P. G. |
Palavras-chave: | α,α-dialkylglycines Peptaibolin Peptide mimetics |
Data: | Fev-2016 |
Resumo(s): | It is reported the membrane permeation studies of a model peptide, Peptaibolin (Ac-Leu-Aib-Leu-Aib-Phol), which is the shortest member of the peptaibols family, and several mimetics incorporating unnatural α,α- dialkylglycines (Deg, Dpg, Ac6c) at the native Aib positions. The model membranes were based on small unilamellar vesicles composed of phosphatidylcholines (egg lecithin, DPPC), phosphatidylglycerols (DPPG, DOPG) and cholesterol, at different compositions and ratios, containing a fluorescent probe encapsulated in their aqueous interior, in order to monitor the permeation process by fluorescence spectroscopy. The obtained results revealed a correlation between the length and bulk of the side chain of the unnatural α,α-dialkylglycines and the ability of the corresponding peptide to permeate the model membranes. |
Tipo: | Comunicação oral |
Descrição: | Comunicação oral OC19 no XV EPI- Iberian Peptide Meeting, Porto, Portugal, 10-12 Fevereiro 2016. |
URI: | https://hdl.handle.net/1822/49293 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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EPI Carina repositorium.pdf | 32,57 kB | Adobe PDF | Ver/Abrir |