Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/49594
Título: | Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression |
Autor(es): | Alves, Nuno Dinis Lopes Oliveira Silva-Correia, Joana Patrício, Patrícia Carvalho Pinheiro, António Maria Restolho Mateus Machado-Santos, Ana R. Loureiro-Campos, Eduardo Morais, Mónica Peixoto, João Miguel Seiça Bessa Sousa, Nuno Pinto, Luísa |
Data: | 14-Mar-2017 |
Editora: | Nature Publishing Group |
Revista: | Translational Psychiatry |
Citação: | Alves, N. D., Correia, J. S., Patrício, P., Mateus-Pinheiro, A., Machado-Santos, A. R., Loureiro-Campos, E., ... & Pinto, L. (2017). Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression. Translational psychiatry, 7(3), e1058 |
Resumo(s): | Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of and recovery from depression. Nevertheless, a high number of remitted patients experience recurrent episodes of depression, remaining unclear how previous episodes impact on behavior and neuroplasticity and/or whether modulation of neuroplasticity is important to prevent recurrent depression. Through re-exposure to an unpredictable chronic mild stress protocol in rats, we observed the re-appearance of emotional and cognitive deficits. Furthermore, treatment with the antidepressants fluoxetine and imipramine was effective to promote sustained reversion of a depressive-like phenotype; however, their differential impact on adult hippocampal neuroplasticity triggered a distinct response to stress re-exposure: while imipramine re-established hippocampal neurogenesis and neuronal dendritic arborization contributing to resilience to recurrent depressive-like behavior, stress re-exposure in fluoxetine-treated animals resulted in an overproduction of adult-born neurons along with neuronal atrophy of granule neurons, accounting for an increased susceptibility to recurrent behavioral changes typical of depression. Strikingly, cell proliferation arrest compromised the behavior resilience induced by imipramine and buffered the susceptibility to recurrent behavioral changes promoted by fluoxetine. This study shows that previous exposure to a depressive-like episode impacts on the behavioral and neuroanatomical changes triggered by subsequent re-exposure to similar experimental conditions and reveals that the proper control of adult hippocampal neuroplasticity triggered by antidepressants is essential to counteract recurrent depressive-like episodes. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/49594 |
DOI: | 10.1038/tp.2017.29 |
ISSN: | 1662-5153 |
e-ISSN: | 2158-3188 |
Versão da editora: | https://www.nature.com/articles/tp201729 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
alves et al_ tp_2017.pdf | 3,27 MB | Adobe PDF | Ver/Abrir |