Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/51224
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Talaia, Gabriel | por |
dc.contributor.author | Gournas, Christos | por |
dc.contributor.author | Saliba, Elie | por |
dc.contributor.author | Antunes, Cláudia Barata | por |
dc.contributor.author | Casal, Margarida | por |
dc.contributor.author | André, Bruno | por |
dc.contributor.author | Diallinas, George | por |
dc.contributor.author | Paiva, Sandra | por |
dc.date.accessioned | 2018-02-28T12:09:23Z | - |
dc.date.issued | 2017-12 | - |
dc.identifier.uri | https://hdl.handle.net/1822/51224 | - |
dc.description.abstract | Eukaryotic cells internalize or recycle their plasma membrane proteins by endocytosis in response to physiological or stress signals imposed by a changing environment. Defects in membrane cargo trafficking lead to protein mislocalization and activation of turnover pathways, which can result into cellular stress and is often related to human diseases. The α-arrestins connect signalling pathways triggered by external stimuli to the endocytosis of specific plasma membrane transporters or receptors. The Saccharomyces cerevisiae lactate transporter Jen1p has been used as a model membrane cargo protein for elucidating aspects of the mechanisms that control the endocytic turnover of specific transporters in response to the presence of glucose. Here, we discover a novel pathway of Jen1p endocytosis and provide further insights on how particular α-arrestins mediate the ubiquitylation of transporters under distinct physiological conditions (presence of cycloheximide or prolonged growth in lactate). | por |
dc.description.sponsorship | The strategic programme UID/BIA/04050/2013 (POCI-01-0145-FEDER-007569) and the project PTDC/BIAMIC/5184/2014 funded by national funds through the FCT I.P. and by the ERDF through the COMPETE 2020 - Programa Operacional Competitividade e Internacionalização (POCI); This work is a result of the project EcoAgriFood: Innovative green products and processes to promote Agri-Food BioEconomy" (operação NORTE-01-0145-FEDER-000009), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). GT acknowledges FCT for the SFRH/BD/86221/2012 PhD grant. | por |
dc.language.iso | eng | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147364/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F86221%2F2012/PT | por |
dc.rights | restrictedAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.title | Signals and mechanisms of endocytosis of eukaryotic lactate transporters | por |
dc.type | conferencePoster | por |
dc.peerreviewed | no | por |
oaire.citationConferenceDate | December 7 - December 9, 2017 | por |
sdum.event.title | MicroBiotec'17 | por |
sdum.event.type | congress | por |
oaire.citationConferencePlace | Porto, Portugal | por |
dc.subject.fos | Ciências Naturais::Ciências Biológicas | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
Aparece nas coleções: | DBio - Comunicações/Communications in Congresses |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Posters_MicroBiotec17 Jen1.pdf Acesso restrito! | 1 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons