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https://hdl.handle.net/1822/51314
Título: | Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice |
Autor(es): | Jiang, Zhihui Wang, Jian Xue, Huiting Wang, Meng Jiang, Hai Liang, Yinku Dias, Alberto Carlos Pires Gregory, Marslin Chen, Chen Zhang, Xiaoying |
Palavras-chave: | Corni fructus Acute alcoholic liver Mice CYP2E1 Oxidative stress Traditional Chinese medicine Hepatoprotective drug Hepatotoxicity |
Data: | 2017 |
Editora: | Taylor & Francis |
Revista: | REDOX REPORT |
Citação: | Jiang, Z., Wang, J., Xue, H., Wang, M., Jiang, H., Liang, Y., ... & Zhang, X. (2017). Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice. Redox Report, 22(6), 338-345 |
Resumo(s): | Background: In Chinese folk medicine, Corni fructus (C. fructus) has traditionally been used to improve liver function, although the mechanism underlying its activity remains unclear. The aim of the present study was to evaluate the protective effects of wild C. fructus methanolic extract against acute alcoholic liver injury.Methods: Alcohol was administered to mice for three consecutive days, either alone or in combination with C. fructus methanolic extract (50, 100, or 200mg/kg body weight/d). Serum and liver tissue were collected from the animals and subjected to biochemical and histopathological analyses.Results:C. fructus significantly alleviated alcohol-induced liver injury by reducing serum alanine aminotransferase, aspartate aminotransferase, and thiobarbituric acid reactive species, inhibiting hydroxyl radicals (center dot OH), and increasing total superoxide dismutase, glutathione peroxidase, and glutathione in the liver (P<0.05). In addition, the C. fructus treatment inhibited the expression and activity of cytochrome P450 2E1 (P<0.05)Conclusions:C. fructus could be a promising natural substance for ameliorating acute alcohol-induced oxidative stress and hepatic injury. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/51314 |
DOI: | 10.1080/13510002.2016.1239867 |
ISSN: | 1351-0002 |
e-ISSN: | 1743-2928 |
Versão da editora: | https://www.tandfonline.com/doi/abs/10.1080/13510002.2016.1239867 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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(2016) jiang2016.pdf | 1,99 MB | Adobe PDF | Ver/Abrir |