Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/53760| Título: | Spectroscopic characterization of a coumarin-labelled therapeutic tetrapeptide |
| Autor(es): | Santos, F. C. Gonçalves, M. Sameiro T. Costa, Susana P. G. |
| Palavras-chave: | AAPV peptide photorelease photocleavable protecting groups |
| Data: | 2015 |
| Editora: | MDPI |
| Citação: | F. C. Santos, M. S. T. Gonçalves, S. P. G. Costa, Spectroscopic characterization of a coumarin-labelled therapeutic tetrapeptide. In Proceedings of the 18th Int. Electron. Conf. Synth. Org. Chem., Sciforum Electronic Conference Series, Vol. 18, 2015, b018. |
| Resumo(s): | The present work describes the synthesis of the tetrapeptide H-Ala-Ala-Pro-Val-NH2 (AAPV), an important inhibitor of the enzyme human neutrophil elastase, labelled at the C-terminus with a 7-methoxycoumarinyl moiety. Photophysical studies were made with spectroscopic characterization by UV-vis and fluorescence spectroscopy in different organic solvents and mixtures with aqueous HEPES solution, in order to simulate physiological conditions. |
| Tipo: | Artigo em ata de conferência |
| URI: | https://hdl.handle.net/1822/53760 |
| ISBN: | 978-3-906980-55-3 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| ecsoc-18_2561_manuscript.pdf | 332,42 kB | Adobe PDF | Ver/Abrir |
