Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/55933
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Soares, Telma Bezerra | por |
dc.contributor.author | Loureiro, Luís | por |
dc.contributor.author | Carvalho, Ana | por |
dc.contributor.author | Real Oliveira, M. Elisabete C.D. | por |
dc.contributor.author | Dias, Alberto Carlos Pires | por |
dc.contributor.author | Sarmento, Bruno | por |
dc.contributor.author | Lúcio, Marlene | por |
dc.date.accessioned | 2018-09-20T16:30:07Z | - |
dc.date.available | 2018-09-20T16:30:07Z | - |
dc.date.issued | 2018-09-14 | - |
dc.date.submitted | 2018-01-05 | - |
dc.identifier.citation | Bezerra Soares, T., Progress in Neurobiology (2018), https://doi.org/10.1016/j.pneurobio.2018.04.004 | por |
dc.identifier.issn | 0301-0082 | por |
dc.identifier.uri | https://hdl.handle.net/1822/55933 | - |
dc.description | Article in press | por |
dc.description.abstract | Age related neurodegenerative disorders (ARND) are presented as the most debilitating and challenging diseases associated with the central nervous system. Despite the advent of active molecules with a positive role on neurodegenerative mechanisms, many of the current therapeutic strategies remain ineffective in treating or preventing ARND. Lipid nanocarriers have emerged as efficient delivery systems with the capability to cross biological barriers, especially the blood brain barrier (BBB). Also, when associated to natural compounds, lipid nanocarriers have demonstrated to be an interesting alternative to ARND therapies with multiple beneficial effects. This comprehensive review focus on state-of-the-art lipid based nanocarriers for the delivery of natural compounds targeting neurodegeneration. A critical analysis of published reports will be also provided giving indications to researchers about the most promising ARND nanotherapy strategies. | por |
dc.description.sponsorship | Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013. Marlene Lúcio acknowledges the exploratory project funded by FCT with the reference IF/00498/2012. Telma Soares acknowledges COMPETE 2020 “Programa Operacional Competitividade e internacionalização” | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147414/PT | por |
dc.rights | openAccess | por |
dc.subject | Lipid nanocarriers | por |
dc.subject | Natural compounds | por |
dc.subject | Blood brain barrier | por |
dc.subject | Neurooxidation | por |
dc.subject | Neuroinflammation | por |
dc.subject | Targeting | por |
dc.subject | Triggering | por |
dc.title | Lipid nanocarriers loaded with natural compounds: Potential new therapies for age related neurodegenerative diseases? | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0301008218300066 | por |
oaire.citationStartPage | 21 | por |
oaire.citationEndPage | 41 | por |
oaire.citationVolume | 168 | por |
dc.identifier.eissn | 1873-5118 | por |
dc.identifier.doi | 10.1016/j.pneurobio.2018.04.004 | por |
dc.identifier.pmid | 29641983 | por |
dc.subject.fos | Ciências Médicas::Biotecnologia Médica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Progress in Neurobiology | por |
Aparece nas coleções: | CDF - FAMO - Artigos/Papers (with refereeing) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Telma Bezerra et al Prog Neur.2018.pdf | 2,61 MB | Adobe PDF | Ver/Abrir |