Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/5748
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Campo DC | Valor | Idioma |
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dc.contributor.author | Reis Filho, Jorge S. | - |
dc.contributor.author | Milanezi, Fernanda | - |
dc.contributor.author | Steele, D. | - |
dc.contributor.author | Savage, K. | - |
dc.contributor.author | Simpson, Pete T. | - |
dc.contributor.author | Nesland, J. M. | - |
dc.contributor.author | Pereira, Emílio M. | - |
dc.contributor.author | Lakhani, Sunil R. | - |
dc.contributor.author | Schmitt, Fernando C. | - |
dc.date.accessioned | 2006-11-06T16:00:34Z | - |
dc.date.available | 2006-11-06T16:00:34Z | - |
dc.date.issued | 2006-07 | - |
dc.identifier.citation | "Histopathology". ISSN 0309-0167. 49:1 (July 2006) 10-21. | eng |
dc.identifier.issn | 0309-0167 | eng |
dc.identifier.uri | https://hdl.handle.net/1822/5748 | - |
dc.description.abstract | Recently, an immunohistochemical panel comprising antibodies against HER2, estrogen receptor (ER), epidermal growth factor receptor (EGFR) and cytokeratin (CK) 5 ⁄ 6 was reported to identify basal-like breast carcinomas, as defined by cDNA microarrays. Our aim was to analyse a series of metaplastic breast carcinomas (MBCs) using this panel plus two other basal markers (CK14 and p63) and progesterone receptor (PR), to define how frequently MBCs show a basal-like immunophenotype. Methods and results: Sixty-five cases were retrieved from the pathology archives of the authors’ institutions and reviewed by three of the authors. Immunohistochemistry with antibodies for HER2, ER, EGFR, CK5 ⁄ 6, CK14 and p63 was performed according to standard methods. All but six cases (91%) showed the typical immunoprofile of basal-like tumours (ER– and HER2–, EGFR+ and ⁄ or CK5 ⁄ 6+). When CK14 and p63 were added to the panel, two additional cases could be classified as basal-like. The majority of MBCs lacked PR, except 4 ⁄ 19 (21%) carcinomas with squamous metaplasia. Conclusions: Our results demonstrate that MBCs show a basal-like phenotype, regardless of the type of metaplastic elements. Moreover, as these neoplasms frequently overexpress EGFR (57%), patients with MBC may benefit from treatment with anti-EGFR drugs. | eng |
dc.language.iso | eng | eng |
dc.publisher | Blackwell Publishing | por |
dc.rights | openAccess | eng |
dc.subject | Carcinosarcoma | eng |
dc.subject | Epidermal growth factor receptor (HER1) | eng |
dc.subject | Myoepithelial | eng |
dc.subject | Sarcomatoid carcinoma | eng |
dc.subject | Immunohistochemistry | eng |
dc.title | Metaplastic breast carcinomas are basal-like tumours | eng |
dc.type | article | por |
dc.peerreviewed | yes | eng |
sdum.number | 1 | eng |
sdum.pagination | 10–21 | eng |
sdum.publicationstatus | published | eng |
sdum.volume | 49 | eng |
oaire.citationStartPage | 10 | por |
oaire.citationEndPage | 21 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 49 | por |
dc.identifier.doi | 10.1111/j.1365-2559.2006.02467.x | por |
dc.identifier.pmid | 16842242 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Histopathology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Histopathology_Sérgio.pdf | 1,9 MB | Adobe PDF | Ver/Abrir |