Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58190
Título: | A silk fibroin hydrogel with reversible sol–gel transition |
Autor(es): | Yin, Zhuping Wu, Feng Xing, Tieling Yadavalli, Vamsi K. Kundu, Subhas C Lu, Shenzhou |
Data: | 2017 |
Editora: | Royal Society of Chemistry |
Revista: | RSC Advances |
Resumo(s): | In this report, a novel silk fibroin hydrogel with a reversible sol-gel transition capacity is presented, in which the base material of this reversible hydrogel is hydrophilic silk fibroin (HSF) obtained by immersing a dried regenerated Bombyx mori silk fibroin (SF) condensate in deionized water (DI water) and collecting its lixivium. The resulting HSF sol can exhibit an enhanced sol-gel transition within several hours at suitable temperatures (25-50 degrees C) without any exterior additive, even at extremely low concentrations (<0.2%, w/v). The HSF gel can perform thixotropic, reversible gel-sol transitions triggered by a facile cycled shear-thinning and resting procedure. Reversible sol-gel transition kinetics analyses and dynamic measurements of the micro-structure transformation during the transition demonstrate that both the beta-sheet self-assembling process and metastable hydrogen bonding (H-bond) interactions among these large scale beta-sheet aggregates play essential roles in the significant enhancement of the reversible HSF sol-gel transition. Due to the reversible, thixotropic sol-gel transitions and suitable viscoelasticity of its shear-thinning system for matching random sizes/shapes, the HSF system is possibly an alternative injectable hydrogel for applications in 3-dimensional (3D) cell culture and tissue repair in situ. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58190 |
DOI: | 10.1039/C7RA02682J |
ISSN: | 2046-2069 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
c7ra02682j.pdf | 2,47 MB | Adobe PDF | Ver/Abrir |