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https://hdl.handle.net/1822/62192
Título: | Competing-risks regression models in analysis of biomarkers as predictors of high-risk human papillomavirus (HPV) infection outcomes and incident CIN in the LAMS cohort |
Autor(es): | Syrjänen, Stina Longhato, Adhemar Sarian, Luis O. Naud, Paulo Derchain, Sophie Rottelli-Martins, Cecilia Tatti, Silvio Branca, Margherita Eržen, Mojca Hammes, Luciano S. Matos, Jean Gontijo, Renata Bragança, Joana Arlindo, Francisco C. Maeda, Mariana Y. S. Costa, Silvano Syrjänen, Kari |
Palavras-chave: | 14-3-3 Proteins Biomarkers Biomarkers, Tumor Cervical Intraepithelial Neoplasia Cervix Uteri Cohort Studies DNA, Viral Disease Progression E1A-Associated p300 Protein Exoribonucleases Female Humans Interleukin-10 Lipocalins Longitudinal Studies Multivariate Analysis Papillomaviridae Papillomavirus Infections Predictive Value of Tests Prognosis Prospective Studies Serpins Uterine Cervical Neoplasms High-risk HPV Incident CIN Viral outcomes Lipocalin PAI-2 (Serpin-B2) p300 IL-10 Stratifin (14-3-3) Competing-risks regression Predictors Longitudinal setting Longitudinal settingHigh-risk HPV Stratifin (14-3-3s) |
Data: | Jul-2013 |
Editora: | Lippincott, Williams & Wilkins |
Revista: | International Journal of Gynecological Pathology |
Citação: | Syrjänen, S., Longhato-Filho, A., Sarian, L. O., et. al. (2013). Competing-risks regression models in analysis of biomarkers as predictors of high-risk human papillomavirus (HPV) infection outcomes and incident CIN in the LAMS cohort. International Journal of Gynecological Pathology, 32(4), 406-415. |
Resumo(s): | To assess the prediction potential of a 5-biomarker panel for detecting high-risk human papillomavirus (HR-HPV) infections and/or cervical intraepithelial neoplasia (CIN) progression. Five biomarkers, lipocalin, plasminogen activator inhibitor-2, p300, interleukin-10, and stratifin, were assessed in cervical biopsies from 225 women of the Latin American Screening Study. Competing-risks regression models were constructed to assess their predictive power for (i) HR-HPV outcomes (negative, transient, or persistent infection) and (ii) CIN outcomes (no progression, incident CIN1, CIN2, or CIN3). p300, LCN2, stratifin were significantly associated with prevalent HR-HPV but lost their significance in multivariate analysis. In the multivariate model, only p300 was an independent predictor of CIN3 (odds ratio=2.63; 95% confidence interval, 1.05-6.61; P=0.039). In univariate competing-risks regression, lipocalin predicted permanent HR-HPV-negative status, but in the multivariate model, IL-10 emerged as a independent predictor of HPV-negative status (subhazard ratio=4.04; 95% confidence interval, 1.81-9.01; P=0.001). The clinical value of the panel in predicting longitudinal outcomes of HR-HPV infection and/or incident CIN is limited. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62192 |
DOI: | 10.1097/PGP.0b013e31826739b1 |
ISSN: | 0277-1691 |
e-ISSN: | 1538-7151 |
Versão da editora: | https://journals.lww.com/intjgynpathology/Abstract/2013/07000/Competing_Risks_Regression_Models_in_Analysis_of.10.aspx |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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10.1097@PGP.0b013e31826739b1.pdf Acesso restrito! | 151,46 kB | Adobe PDF | Ver/Abrir |