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https://hdl.handle.net/1822/62303
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Campo DC | Valor | Idioma |
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dc.contributor.author | Mondanelli, Giada | por |
dc.contributor.author | Iacono, Alberta | por |
dc.contributor.author | Carvalho, Agostinho | por |
dc.contributor.author | Orabona, Ciriana | por |
dc.contributor.author | Volpi, Claudia | por |
dc.contributor.author | Pallotta, Maria T. | por |
dc.contributor.author | Matino, Davide | por |
dc.contributor.author | Esposito, Susanna | por |
dc.contributor.author | Grohmann, Ursula | por |
dc.date.accessioned | 2019-11-21T12:46:30Z | - |
dc.date.available | 2020-05-01T06:00:21Z | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 1568-9972 | - |
dc.identifier.uri | https://hdl.handle.net/1822/62303 | - |
dc.description.abstract | In mammals, amino acid metabolism has evolved to control immune responses. Autoimmune diseases are heterogeneous conditions that involve the breakdown of tolerogenic circuitries and consequent activation of autoreactive immune cells. Therefore, critical enzymes along amino acid degradative pathways may be hijacked to keep in check autoimmunity. We examined here current knowledge of indoleamine 2,3-dioxygenase 1 (IDO1) and arginase 1 (ARG1), the main enzymes catabolizing tryptophan and arginine, respectively, in organ-specific and systemic autoimmune diseases as well as in the development of autoantibodies to therapeutic proteins. At variance with neoplastic contexts, in which it is known to act as a pure immunosuppressive molecule, ARG1 exhibited a protective or pathogenetic profile, depending on the disease. In contrast, in several autoimmune conditions, the bulk of data indicated that drugs capable of potentiating IDO1 expression and activity may represent valuable therapeutic tools and that IDO1-based immunotherapeutic protocols could be more effective if tailored to the genetic profile of individual patients. | por |
dc.description.sponsorship | This work was supported by the European Research Council (338954-DIDO and 780807-DIDO-MS, both to U.G.) and the Italian Ministry of Education, Universities, and Research (PRIN2015- 20155C2PP7 to C.V.). A.C. was supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-0145-FEDER-000013), and the Fundação para a Ciência e Tecnologia (FCT) (IF/00735/2014). | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/338954/EU | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/780807/EU | - |
dc.relation | info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00735%2F2014%2FCP1212%2FCT0001/PT | - |
dc.rights | openAccess | por |
dc.subject | Amino Acids | por |
dc.subject | Animals | por |
dc.subject | Arginase 1 | por |
dc.subject | Autoimmune Diseases | por |
dc.subject | Humans | por |
dc.subject | Immunosuppressive Agents | por |
dc.subject | Indoleamine 2,3-dioxygenase 1 | por |
dc.subject | Metabolic Networks and Pathways | por |
dc.subject | Molecular Targeted Therapy | por |
dc.subject | Tryptophan | por |
dc.subject | Arginine metabolism | por |
dc.subject | Host genetics | por |
dc.subject | Immune regulation | por |
dc.subject | Tryptophan metabolism | por |
dc.title | Amino acid metabolism as drug target in autoimmune diseases | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | 334 | por |
oaire.citationEndPage | 348 | por |
oaire.citationIssue | 4 | por |
oaire.citationVolume | 18 | por |
dc.identifier.eissn | 1873-0183 | - |
dc.identifier.doi | 10.1016/j.autrev.2019.02.004 | por |
dc.identifier.pmid | 30797943 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Autoimmunity Reviews | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Mondanelli G et al. Autoimmun Rev.pdf | 1,07 MB | Adobe PDF | Ver/Abrir |