TET enzymes in neurophysiology and brain function

doi:10.1016/j.neubiorev.2019.05.006

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/62316

Registo completo

Campo DC	Valor	Idioma
dc.contributor.author	Antunes, Cláudia	por
dc.contributor.author	Sousa, Nuno	por
dc.contributor.author	Pinto, Luísa	por
dc.contributor.author	Marques, C. Joana	por
dc.date.accessioned	2019-11-21T15:45:24Z	-
dc.date.available	2024-01-01T07:00:32Z	-
dc.date.issued	2019	-
dc.identifier.citation	Antunes, C., Sousa, N., Pinto, L., & Marques, C. J. (2019). TET enzymes in neurophysiology and brain function. Neuroscience & Biobehavioral Reviews.	por
dc.identifier.issn	0149-7634	-
dc.identifier.uri	https://hdl.handle.net/1822/62316	-
dc.description.abstract	The dynamic nature of epigenetic DNA modifications is crucial for regulating gene expression in an experience-dependent manner and, thus, a potential mediator of neuronal plasticity and behavior. The discovery of the involvement of 5-hydroxymethylcytosine (5hmC) and Ten Eleven Translocation (TET) family of enzymes in the demethylation pathway uncovered a potential link between neuronal TET protein function and cognitive processes. In this review, we provide an overview on how profile of 5hmC and TET enzymes are powerful mechanisms to explain neuronal plasticity and long-term behaviors, such as cognition. More specifically, we discuss how the current knowledge integrates the function of each TET enzyme in neurophysiology and brain function.	por
dc.description.sponsorship	Portuguese Foundation for Science and Technology (FCT) fellowships (PD/BD/106049/2015 to C.A., IF/01079/2014 to L.P. and IF/00047/2012 and CEECIND/00371/2017 to C.J.M); FCT project grant (PTDC/BIA-BCM/121276/2010) to C.J.M; EpiGeneSys Small Collaborative project to L.P.; BIAL Foundation Grant427/14 to L.P.; Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER; NORTE-01-0145-FEDER-000013); FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and National Funds, through the FCT (POCI-01-0145-FEDER-007038)	por
dc.language.iso	eng	por
dc.publisher	Elsevier 1	por
dc.relation	info:eu-repo/grantAgreement/FCT/FARH/PD%2FBD%2F106049%2F2015/PT	-
dc.relation	info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01079%2F2014%2FCP1212%2FCT0017/PT	-
dc.relation	info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00047%2F2012%2FCP0177%2FCT0001/PT	-
dc.relation	info:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00371%2F2017%2FCP1413%2FCT0002/PT	-
dc.relation	info:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FBIA-BCM%2F121276%2F2010/PT	-
dc.rights	openAccess	por
dc.subject	Neuronal plasticity	por
dc.subject	Behavior	por
dc.subject	Epigenetics	por
dc.subject	TET enzymes	por
dc.subject	5hmC	por
dc.title	TET enzymes in neurophysiology and brain function	por
dc.type	article	por
dc.peerreviewed	yes	por
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S014976341830856X	por
dc.comments	48 meses	por
oaire.citationStartPage	337	por
oaire.citationEndPage	344	por
oaire.citationVolume	102	por
dc.identifier.eissn	1873-7528	-
dc.identifier.doi	10.1016/j.neubiorev.2019.05.006	por
dc.identifier.pmid	31078565	por
dc.subject.fos	Ciências Médicas::Medicina Básica	por
dc.subject.wos	Science & Technology	por
sdum.journal	Neuroscience and Biobehavioral Reviews	por
Aparece nas coleções:	ICVS - Artigos em revistas internacionais / Papers in international journals