Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62319
Título: | Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors |
Autor(es): | Coimbra, Bárbara Soares-Cunha, Carina Vasconcelos, Nivaldo António Portela Domingues, Ana Verónica Borges, Sónia Sousa, Nuno Rodrigues, Ana João |
Data: | 12-Set-2019 |
Editora: | Nature Research |
Revista: | Nature Communications |
Citação: | Coimbra, B., Soares-Cunha, C., Vasconcelos, N. A., Domingues, A. V., Borges, S., Sousa, N., & Rodrigues, A. J. (2019). Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors. Nature communications, 10(1), 1-15. |
Resumo(s): | The laterodorsal tegmentum (LDT) is associated with reward considering that it modulates VTA neuronal activity, but recent anatomical evidence shows that the LDT also directly projects to nucleus accumbens (NAc). We show that the majority of LDT-NAc inputs are cholinergic, but there is also GABAergic and glutamatergic innervation; activation of LDT induces a predominantly excitatory response in the NAc. Non-selective optogenetic activation of LDT-NAc projections in rats enhances motivational drive and shifts preference to an otherwise equal reward; whereas inhibition of these projections induces the opposite. Activation of these projections also induces robust place preference. In mice, specific activation of LDT-NAc cholinergic inputs (but not glutamatergic or GABAergic) is sufficient to shift preference, increase motivation, and drive positive reinforcement in different behavioral paradigms. These results provide evidence that LDT-NAc projections play an important role in motivated behaviors and positive reinforcement, and that distinct neuronal populations differentially contribute for these behaviors. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62319 |
DOI: | 10.1038/s41467-019-11557-3 |
ISSN: | 2041-1723 |
e-ISSN: | 2041-1723 |
Versão da editora: | https://www.nature.com/articles/s41467-019-11557-3#citeas |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Role of laterodorsal tegmentum projections tonucleus accumbens in reward-related behaviors.pdf | 2,7 MB | Adobe PDF | Ver/Abrir |