Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/63908
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Dias, Maria Inês | por |
dc.contributor.author | Barreira, João C. M. | por |
dc.contributor.author | Calhelha, Ricardo C. | por |
dc.contributor.author | Queiroz, Maria João R. P. | por |
dc.contributor.author | Oliveira, M. Beatriz P. P. | por |
dc.contributor.author | Soković, Marina | por |
dc.contributor.author | Ferreira, Isabel C. F. R. | por |
dc.date.accessioned | 2020-02-13T11:37:55Z | - |
dc.date.available | 2020-02-13T11:37:55Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2314-6133 | por |
dc.identifier.uri | https://hdl.handle.net/1822/63908 | - |
dc.description | "Article ID 520464" | por |
dc.description.abstract | Natural matrices are important sources of new antitumor and antimicrobial compounds. Species such as Laurus nobilis L. (laurel) might be used for this purpose, considering its medicinal properties. Herein, in vitro activity against human tumor cell lines, bacteria, and fungi was evaluated in enriched phenolic extracts. Specifically, methanol and aqueous extracts of wild and cultivated samples of L. nobilis were compared considering different phenolic groups. Principal component analysis (PCA) was applied to understand how each extract acts differentially against specific bacteria, fungi, and selected human tumor cell lines. In general, the extract type induced the highest differences in bioactivity of laurel samples. However, from the PCA biplot, it became clear that wild laurel samples were higher inhibitors of tumor cell lines (HeLa, MCF7, NCI-H460, and HCT15). HepG2 had the same response to laurel from wild and cultivated origin. It was also observed that methanolic extracts tended to have higher antimicrobial activity, except against A. niger, A. fumigatus, and P. verrucosum. The differences in bioactivity might be related to the higher phenolic contents in methanolic extracts. These results allow selecting the extract type and/or origin with highest antibacterial, antifungal, and antitumor activity. | por |
dc.description.sponsorship | The authors are grateful to Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) for the financial support to CIMO (strategic project PEst-OE/AGR/UI0690/2011) and REQUIMTE (PEst-C/EQB/LA0006/2011). M. I. Dias, R. Calhelha, and J. C. M. Barreira also thank FCT, POPHQREN, and FSE for their Grants (SFRH/BD/84485/2012, SFRH/BPD/ 68344/2010, and BPD/72802/2010). The authors also thank to Serbian Ministry of Education and Science for financial support (grant number 173032). | por |
dc.language.iso | eng | por |
dc.publisher | Hindawi Limited | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F84485%2F2012/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F72802%2F2010/PT | por |
dc.rights | openAccess | por |
dc.subject | Anti-Infective Agents | por |
dc.subject | Antineoplastic Agents | por |
dc.subject | Bacteria | por |
dc.subject | Cell Line, Tumor | por |
dc.subject | Drug Screening Assays, Antitumor | por |
dc.subject | Fungi | por |
dc.subject | Humans | por |
dc.subject | Laurus | por |
dc.subject | Methanol | por |
dc.subject | Microbial Sensitivity Tests | por |
dc.subject | Phenols | por |
dc.subject | Plant Extracts | por |
dc.subject | Principal Component Analysis | por |
dc.title | Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different origins | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 10 | por |
oaire.citationVolume | 2014 | por |
dc.identifier.eissn | 2314-6141 | por |
dc.identifier.doi | 10.1155/2014/520464 | por |
dc.identifier.pmid | 24826380 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Biomed Research International | por |
oaire.version | VoR | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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520464.pdf | 1,24 MB | Adobe PDF | Ver/Abrir |