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https://hdl.handle.net/1822/65970
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Campo DC | Valor | Idioma |
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dc.contributor.author | Zhao, Hongqiong | por |
dc.contributor.author | Jiang, Zhihui | por |
dc.contributor.author | Chang, Xuemei | por |
dc.contributor.author | Xue, Huiting | por |
dc.contributor.author | Yahefu, Wumaierjiang | por |
dc.contributor.author | Zhang, Xiaoying | por |
dc.date.accessioned | 2020-07-13T15:59:02Z | - |
dc.date.available | 2020-07-13T15:59:02Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Zhao H, Jiang Z, Chang X, Xue H, Yahefu W and Zhang X (2018) 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice. Front. Pharmacol. 9:653. doi: 10.3389/fphar.2018.00653 | por |
dc.identifier.issn | 1663-9812 | por |
dc.identifier.uri | https://hdl.handle.net/1822/65970 | - |
dc.description.abstract | Acetaminophen (APAP) overdose is the principal cause of drug-induced acute liver failure. 4-hydroxyphenylacetic acid (4-HPA), a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. This study seeks to investigate the ability of 4-HPA to protect against APAP-induced hepatotoxicity, as well as the putative mechanisms involved. Mice were treated with 4-HPA (6, 12, or 25 mg/kg) for 3 days, 1 h after the last administration of 4-HPA, a single dose of APAP was intraperitoneally infused for mice. APAP caused a remarkable increase of oxidative stress markers, peroxynitrite formation, and fewer activated phase II enzymes. 4-HPA increased Nrf2 translocation to the nucleus and enhanced the activity of phase II and antioxidant enzymes, and could thereby ameliorate APAP-induced liver injury. Studies reveal that 4-HPA, as an active area of bioactive dietary constituents, could protect the liver against APAP-induced injury, implying that 4-HPA could be a new promising strategy and natural hepatoprotective drug. | por |
dc.description.sponsorship | This work was supported by National Key Research and Development Program of China (Grant No. 2017YFD0501400), SCO Regional collaborative innovation project (Grant No. 2016E03012), Xinjiang; the Key Construction Program of International Cooperation Base in S&T, Shaanxi Province (Grant No. 2015SD0018), Program for Science & Technology Innovation Talents in Universities of Henan Province (Grant No. 18HASTIT035], China strategic program UID/BIA/04050/2013 (POCI-01-0145-FEDER-007569) funded by national funds through the FCT I.P., by the Ministerio da Ciencia, Tecnologia e Ensino Superior (MCTES) and by the ERDF through the COMPETE2020 - Programa Operacional Competitividade e Internacionalizacao (POCI), Portugal. | por |
dc.language.iso | eng | por |
dc.publisher | Frontiers Media S.A. | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147364/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | polyphenols | por |
dc.subject | 4-hydroxyphenylacetic acid 4-HPA | por |
dc.subject | acetaminophen APAP | por |
dc.subject | hepatotoxicity | por |
dc.subject | oxidative stress | por |
dc.subject | nuclear factor erythroid 2-related factor | por |
dc.subject | Nrf2 | por |
dc.title | 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fphar.2018.00653/full | por |
oaire.citationIssue | JUN | por |
oaire.citationVolume | 9 | por |
dc.identifier.doi | 10.3389/fphar.2018.00653 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Frontiers in Pharmacology | por |
oaire.version | VoR | por |
Aparece nas coleções: | DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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fphar-09-00653.pdf | 3,22 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons