Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/66192
Título: | Citalopram administration does not promote function or histological recovery after spinal cord injury |
Autor(es): | Lima, Rui Monteiro, Susana Gomes, Eduardo Domingos Correia Vasconcelos, Natália L. Assunção-Silva, Rita Morais, Mónica Salgado, A. J. Silva, Nuno André Martins |
Palavras-chave: | spinal cord injury citalopram SSRI motor recovery 5-HT |
Data: | 2020 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | International Journal of Molecular Sciences |
Citação: | Lima, R.; Monteiro, S.; Gomes, E.D.; Vasconcelos, N.L.; Assunção-Silva, R.; Morais, M.; Salgado, A.J.; Silva, N.A. Citalopram Administration Does Not Promote Function or Histological Recovery after Spinal Cord Injury. Int. J. Mol. Sci. 2020, 21, 5062. |
Resumo(s): | Citalopram is a selective serotonin reuptake inhibitor, and although widely used as an antidepressant, this drug has also demonstrated interesting repairing properties leading to motor recovery and pathology amelioration in animal models of stroke and degeneration. Here, we tested the efficacy of both 7-day and 8-week citalopram treatment in a contusive spinal cord injury (SCI) rat model. A combination of behavioral tests, histological and serum cytokine analysis was used to assess overall recovery. Despite promoting a mild reduction of inflammatory cells as well as an early, but transient increase of specific serum cytokines, citalopram administration showed no overall beneficial effects on motor performance or lesion extension. Our results do not support citalopram treatment as a therapeutic strategy for SCI. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/66192 |
DOI: | 10.3390/ijms21145062 |
ISSN: | 1661-6596 |
e-ISSN: | 1422-0067 |
Versão da editora: | https://www.mdpi.com/1422-0067/21/14/5062 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
ijms-21-05062.pdf | 4,95 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons