Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/67152
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Gonçalves, Samuel Martins | por |
dc.contributor.author | Lagrou, Katrien | por |
dc.contributor.author | Oliveira, Cláudio Manuel Duarte | por |
dc.contributor.author | Maertens, Johan A. | por |
dc.contributor.author | Cunha, Cristina Amorim | por |
dc.contributor.author | Carvalho, Agostinho | por |
dc.date.accessioned | 2020-09-29T15:24:22Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Gonçalves, S. M., Lagrou, K., Duarte-Oliveira, C., et. al. (2017). The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungal diseases. Virulence, 8(6), 673–684 | por |
dc.identifier.issn | 2150-5594 | - |
dc.identifier.uri | https://hdl.handle.net/1822/67152 | - |
dc.description.abstract | Filamentous fungi of the genus Aspergillus are responsible for several superficial and invasive infections and allergic syndromes. The risk of infection and its clinical outcome vary significantly even among patients with similar predisposing clinical factors and pathogen exposure. There is increasing evidence that the individual microbiome supervises the outcome of the host-fungus interaction by influencing mechanisms of immune regulation, inflammation, metabolism, and other physiological processes. Microbiome-mediated mechanisms of resistance allow therefore the control of fungal colonization, preventing the onset of overt disease, particularly in patients with underlying immune dysfunction. Here, we review this emerging area of research and discuss the contribution of the microbiota (and its dysbiosis), including its immunoregulatory properties and relationship with the metabolic activity of commensals, to respiratory fungal diseases. Finally, we highlight possible strategies aimed at decoding the microbiome-metabolome dialog and at its exploitation toward personalized medical interventions in patients at high risk of infection. | por |
dc.description.sponsorship | Merieux Research Grant 2016 from Institut Merieux, the Northern Portugal Regional Operational Program (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-014545-FEDER000013), and by Fundação (IF/00735/2014 to A.C., and SFRH/BPD/96176/2013 to C.C.) | por |
dc.language.iso | eng | por |
dc.publisher | Taylor and Francis | por |
dc.rights | restrictedAccess | por |
dc.subject | Animals | por |
dc.subject | Aspergillosis | por |
dc.subject | Aspergillus | por |
dc.subject | Dysbiosis | por |
dc.subject | Fungi | por |
dc.subject | Host-Pathogen Interactions | por |
dc.subject | Humans | por |
dc.subject | Inflammation | por |
dc.subject | Metabolome | por |
dc.subject | Mice | por |
dc.subject | Microbiota | por |
dc.subject | Mycoses | por |
dc.subject | Precision Medicine | por |
dc.subject | Respiratory Tract Infections | por |
dc.subject | Signal Transduction | por |
dc.subject | Symbiosis | por |
dc.subject | antifungal immunity | por |
dc.subject | fungal disease | por |
dc.subject | host genetics | por |
dc.subject | microbiome | por |
dc.subject | personalized medicine | por |
dc.title | The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungal diseases | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.tandfonline.com/doi/full/10.1080/21505594.2016.1257458 | por |
oaire.citationStartPage | 673 | por |
oaire.citationEndPage | 684 | por |
oaire.citationIssue | 6 | por |
oaire.citationVolume | 8 | por |
dc.identifier.eissn | 2150-5608 | - |
dc.identifier.doi | 10.1080/21505594.2016.1257458 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 27820674 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Virulence | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Goncalves-2016-The-microbiome-metabolome-crosstalk.pdf Acesso restrito! | 1,29 MB | Adobe PDF | Ver/Abrir |