Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/67645
Título: | Recruitment of antigen-specific CD8+ T cells in response to infection is markedly efficient |
Autor(es): | Heijst, Jeroen W. J. van Gerlach, Carmen Swart, Erwin Sie, Daoud Alves, Cláudio Nunes Kerkhoven, Ron M. Arens, Ramon Correia-Neves, M Schepers, Koen Schumacher, Ton N. M. |
Palavras-chave: | Adoptive Transfer Ampicillin Animals Anti-Bacterial Agents Antigens Antigens, Bacterial Antigens, Viral CD8-Positive T-Lymphocytes Dendritic Cells Epitopes Genes, T-Cell Receptor alpha Genes, T-Cell Receptor beta Influenza A virus Listeriosis Lymphocyte Count Mice Mice, Inbred C57BL Mice, Transgenic Molecular Sequence Data Orthomyxoviridae Infections Ovalbumin Receptors, Antigen, T-Cell, alpha-beta Spleen Vaccinia Virus Diseases Lymphocyte Activation |
Data: | 2009 |
Editora: | American Association for the Advancement of Science |
Revista: | Science |
Resumo(s): | The magnitude of antigen-specific CD8+ T cell responses is not fixed but correlates with the severity of infection. Although by definition T cell response size is the product of both the capacity to recruit naïve T cells (clonal selection) and their subsequent proliferation (clonal expansion), it remains undefined how these two factors regulate antigen-specific T cell responses. We determined the relative contribution of recruitment and expansion by labeling naïve T cells with unique genetic tags and transferring them into mice. Under disparate infection conditions with different pathogens and doses, recruitment of antigen-specific T cells was near constant and close to complete. Thus, naïve T cell recruitment is highly efficient, and the magnitude of antigen-specific CD8+ T cell responses is primarily controlled by clonal expansion. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67645 |
DOI: | 10.1126/science.1175455 |
ISSN: | 0036-8075 |
e-ISSN: | 1095-9203 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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vanheijst2009.pdf Acesso restrito! | 629,22 kB | Adobe PDF | Ver/Abrir |