Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/67651
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Syrjänen, Stina | por |
dc.contributor.author | Naud, Paulo | por |
dc.contributor.author | Sarian, Luis | por |
dc.contributor.author | Derchain, Sophie | por |
dc.contributor.author | Roteli-Martins, Cecilia | por |
dc.contributor.author | Longatto, Adhemar | por |
dc.contributor.author | Tatti, Silvio | por |
dc.contributor.author | Branca, Margherita | por |
dc.contributor.author | Erzen, Mojca | por |
dc.contributor.author | Hammes, L. S. | por |
dc.contributor.author | Costa, S. | por |
dc.contributor.author | Syrjänen, Kari | por |
dc.date.accessioned | 2020-10-22T14:44:30Z | - |
dc.date.issued | 2009-12 | - |
dc.identifier.citation | Syrjänen, S., Naud, P., Sarian, L., Derchain, S., et. al. (2009). Immunosuppressive cytokine Interleukin-10 (IL-10) is up-regulated in high-grade CIN but not associated with high-risk human papillomavirus (HPV) at baseline, outcomes of HR-HPV infections or incident CIN in the LAMS cohort. Virchows Archiv, 455(6), 505-515 | por |
dc.identifier.issn | 0945-6317 | - |
dc.identifier.uri | https://hdl.handle.net/1822/67651 | - |
dc.description.abstract | Bypassing the local immunological defense reactions in the cervix is one of the prerequisites for human papillomaviruses (HPV) infections to progress to intraepithelial neoplasia (CIN). The role of potent immunosuppressive cytokines, e.g., interleukin-10 (IL-10), depressing these local virus-specific immunological responses is incompletely studied. To assess, whether IL-10 expression in cervical HPV lesions has any implications in the outcome of HPV infections or disease progression to CIN. Baseline cervical biopsies from 225 women of the LAMS study sub-cohort were analyzed for IL-10 expression using immunohistochemistry, to assess its associations with CIN grade, and high-risk HPV (HR-HPV) at baseline, as well as in predicting outcomes of HR-HPV infections, and development of incident CIN1+ and CIN2+ in this longitudinal setting. Expression of IL-10 in cervical lesions was up-regulated most often in high-grade CIN, and IL-10 over-expression retained its value as independent predictor of CIN2+ (odds ratio (OR) = 4.92) and CIN3+ (OR = 7.51) also in multivariate model, including HR-HPV and several known covariates of IL-10 expression. Up-regulation was not related to HR-HPV detection, and showed no relationship to HR-HPV viral loads. Using longitudinal predictive indicators (SE, SP, PPV, NPV), IL-10 expression was of no value in predicting (1) the outcomes of HR-HPV infections, or (2) the surrogate endpoints (incident CIN1+, CIN2+) of progressive disease. IL-10 over-expression (along with HR-HPV) was one of the independent covariates of CIN2/3. This immunosuppressive cytokine might play an important role in creating a microenvironment that favors progressive cervical disease and immune evasion by HR-HPV. | por |
dc.description.sponsorship | European Commission, INCO-DEV Programme (Contract# ICA4-CT-2001-10013). The generous contribution of former DIGENE Inc. (USA) donating the HC2 tests at our disposal is gratefully acknowledged. | por |
dc.language.iso | eng | por |
dc.publisher | Springer | por |
dc.rights | restrictedAccess | por |
dc.subject | Adult | por |
dc.subject | Cervical Intraepithelial Neoplasia | por |
dc.subject | Cohort Studies | por |
dc.subject | DNA, Viral | por |
dc.subject | Disease Progression | por |
dc.subject | Female | por |
dc.subject | Gene Expression Regulation, Neoplastic | por |
dc.subject | Humans | por |
dc.subject | Immunohistochemistry | por |
dc.subject | Interleukin-10 | por |
dc.subject | Papillomavirus Infections | por |
dc.subject | Prospective Studies | por |
dc.subject | Up-Regulation | por |
dc.subject | Uterine Cervical Neoplasms | por |
dc.subject | Vaginal Smears | por |
dc.subject | High-risk HPV | por |
dc.subject | Immunosuppressive cytokines | por |
dc.subject | Th cells | por |
dc.subject | CIN | por |
dc.subject | Viral outcomes | por |
dc.subject | Disease progression | por |
dc.subject | Longitudinal predictive values | por |
dc.subject | Surrogate endpoints | por |
dc.title | Immunosuppressive cytokine Interleukin-10 (IL-10) is up-regulated in high-grade CIN but not associated with high-risk human papillomavirus (HPV) at baseline, outcomes of HR-HPV infections or incident CIN in the LAMS cohort | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s00428-009-0850-7 | por |
oaire.citationStartPage | 505 | por |
oaire.citationEndPage | 515 | por |
oaire.citationIssue | 6 | por |
oaire.citationVolume | 455 | por |
dc.identifier.eissn | 1432-2307 | - |
dc.identifier.doi | 10.1007/s00428-009-0850-7 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 19908064 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Virchows Archiv | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Syrjanen-2009-Immunosuppressive-cytokine-interleu.pdf Acesso restrito! | 361,85 kB | Adobe PDF | Ver/Abrir |