Research lines developed by the 3 Research Domains of the ICVS, Infectious Diseases , Neurosciences and Development & Neoplasia :

A – Infectious Diseases
   • The study of the neurodegenerative disorder Batten disease
   • Human genetic factors predisposing susceptibility to invasive fungal infections
   • Identification of clinically relevant fungi causing systemic mycosis
   • Cellular and molecular studies in the pathogenic fungi Paracoccidioides brasiliensis: Dimorphism and its regulation by steroid hormones
   • Epidemiology profile of dermatophytosis in Braga
   • Elucidation of the mechanisms of action of non-conventional antifungal agents
   • Exploitation of yeast as a model to study mitochondrial diseases and neurodegenerative disorder Batten disease
   • Apoptotic pathway(s) in Saccharomyces cerevisiae: proteomic profile and metacaspase-interactive molecules
   • Identification of pathogenic fungi secreted compounds
• Biology of infection in mycobacteriosis of difficult treatment- Buruli Ulcer
   • Understanding BCG infection/vaccination; role of IFN-gamma and IL-17
• Role of anti-inflammatory cytokines in allograft rejection
   • Expression and activation of murine Toll-like receptors in B lymphocytes
• Development of drug delivery systems for the treatment of mycobaceriosis

B – Neurosciences
   • Neuronal turnover regulation and its relevance for pathology
   • From stress to cognition and pain: the role of corticosteroids and CRF
   • Descending pain modulating networks
   • Anatomical basis for the sensorymotor processing in the laryngeal mucosa
   • Improving treatment of trigeminal neuralgia (TN) and epidemiology of TN in Portugal
   • Studies on the role of transthyretin in energy metabolism
• Molecular basis of schizophrenia: the retinoid and thyroid hormone hypotheses
   • Characterization of the iodine status in young women from Minho region and its relationship with the psychomotor development of the newborns
   • Functional genomics of Machado-Joseph disease
   • Rett Syndrome
   • Functional characterization of the MECP2 3'UTR

C – Development and Neoplasia
   • Analysis of myopithelial component role in breast cancer development
   • Analysis of DNA repair gene polymorphisms in a group of breast cancer patients from Portuguese origin
   • Study of lymphangiogenesis in vascular lesions and breast cancer
   • Analysis of receptor tyrosine kinases and intracellular signaling pathway alterations in gliomas
   • Role of COX-2 and TP in the antitumoral response to Capecitabine in Hand and Foot Syndrome animal model
   • The molecular clock is operating during limb bud development
   • Characterization of the molecular clock components by using the yeast Two-Hybrid technology
   • Subtraction screening to identify medial presomitic mesoderm genes
   • Molecular and temporal characterization of the rostral-most somites in early somitic stages of the chick embryo
   • The role of ghrelin in normal and hypoplastic fetal lung
   • Prognostic factors in experimental and human congenital diaphragmatic hernia (CDH)
   • The role of inflammatory mediators in normal and hypoplastic lung
   • Induction of fetal lung growth by overexpression of growth factors through viral gene transfer in CDH rat model
   • In utero fate mapping of Aorta-Gonad-Mesonephros cells
   • Myocardium hypertrophy and pregnancy
   • Fetal heart development in congenital diaphragmatic hernia
   • Ghrelin expression and function during fetal heart development

Transthyretin as a thyroid hormone carrier: function revisited

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