Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/68693
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Pires, Diana P. | por |
dc.contributor.author | Costa, Ana Rita | por |
dc.contributor.author | Pinto, Graça | por |
dc.contributor.author | Meneses, Luciana | por |
dc.contributor.author | Azeredo, Joana | por |
dc.date.accessioned | 2020-12-22T21:54:07Z | - |
dc.date.available | 2020-12-22T21:54:07Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.citation | Pires, Diana P.; Costa, Ana Rita; Pinto, Graça; Meneses, Luciana; Azeredo, Joana, Current challenges and future opportunities of phage therapy. FEMS Microbiology Reviews, 44(6), 684-700, 2020 | por |
dc.identifier.issn | 0168-6445 | por |
dc.identifier.uri | https://hdl.handle.net/1822/68693 | - |
dc.description.abstract | Antibiotic resistance is a major public health challenge worldwide, whose implications for global health might be devastating if novel antibacterial strategies are not quickly developed. As natural predators of bacteria, (bacterio)phages may play an essential role in escaping such a dreadful future. The rising problem of antibiotic resistance has revived the interest in phage therapy and important developments have been achieved over the last years. But where do we stand today and what can we expect from phage therapy in the future? This is the question we set to answer in this review. Here, we scour the outcomes of human phage therapy clinical trials and case reports, and address the major barriers that stand in the way of using phages in clinical settings. We particularly address the potential of phage resistance to hinder phage therapy and discuss future avenues to explore the full capacity of phage therapy. | por |
dc.description.sponsorship | This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the project PTDC/BBB-BSS/6471/2014 ( POCI-01–0145-FEDER-016643); the strategic funding of UIDB/04469/2020 unit and BioTecNorte operation (NORTE-01–0145-FEDER-000004) funded by European Regional Development Fund under the scope of Norte2020–Programa Operacional Regional do Norte. DPP and GP are supported by FCT through the grants SFRH/BPD/116187/2016 and SFRH/BD/117365/2016, respectively. | por |
dc.language.iso | eng | por |
dc.publisher | Oxford University Press | por |
dc.relation | PTDC/BBB-BSS/6471/2014 | por |
dc.relation | UIDB/04469/2020 | por |
dc.relation | SFRH/BPD/116187/2016 | por |
dc.relation | SFRH/BD/117365/2016 | por |
dc.rights | openAccess | por |
dc.subject | Clinical trials | por |
dc.subject | phage resistance | por |
dc.subject | phage engineering | por |
dc.subject | phage cocktails | por |
dc.subject | regulatory framework | por |
dc.subject | One-Health | por |
dc.title | Current challenges and future opportunities of phage therapy | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://academic.oup.com/femsre | por |
dc.comments | CEB54079 | por |
oaire.citationStartPage | 684 | por |
oaire.citationEndPage | 700 | por |
oaire.citationIssue | 6 | por |
oaire.citationVolume | 44 | por |
dc.date.updated | 2020-12-22T13:18:07Z | - |
dc.identifier.doi | 10.1093/femsre/fuaa017 | por |
dc.identifier.pmid | 32472938 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | FEMS Microbiology Reviews | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54079_1.pdf | 1,14 MB | Adobe PDF | Ver/Abrir |