Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/69645
Título: | Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications |
Autor(es): | Teixeira, Jean Valdir Uchôa Maia, F. Raquel Carvalho, Mariana R. Reis, R. L. Oliveira, J. M. Lisboa-Filho, Paulo Noronha Claro, Ana Paula Rosifni Alves |
Palavras-chave: | Core/shell Cytotoxicity Gallium incorporation Nanoparticle synthesis |
Data: | Jan-2021 |
Editora: | Future Medicine |
Revista: | Nanomedicine |
Citação: | Teixeira J. V. U., Maia F. R., Carvalho M. R., Reis R. L., Oliveira J. M., Lisboa-Filho P. N., Claro A. P. R. A. Synthesis of mussel-inspired poly(dopamine)-gallium nanoparticles for biomedical applications, Nanomedicine, doi:10.2217/nnm-2020-0312, 2021 |
Resumo(s): | Aim: In this work, we established a simple, controlled, and reproducible method to synthesize gallium-coated polydopamine (PDA) nanoparticles. Methods: Polydopamine was synthetized in the alkali medium with posterior gallium shell formation due to ion chelation on the nanoparticle surface. Results: The obtained results with EDS spectra confirmed the incorporation of gallium on PDA surface. The cytotoxicity of Ga-coated PDA nanoparticles was evaluated in vitro at different concentrations in contact with human adipose-derived stem cells (hASCs). Further cell analysis also demonstrated the benefit of Ga-coated PDA, which increased the cell proliferation rate compared to non-coated PDA. Conclusion: This study indicated that gallium could work as an appropriate shell for PDA particles, inducing cell proliferation at the analyzed concentrations. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/69645 |
DOI: | 10.2217/nnm-2020-0312 |
ISSN: | 1743-5889 |
e-ISSN: | 1748-6963 |
Versão da editora: | https://www.futuremedicine.com/doi/10.2217/nnm-2020-0312 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20412-Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications.pdf Acesso restrito! | 4,25 MB | Adobe PDF | Ver/Abrir |