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https://hdl.handle.net/1822/70945
Título: | Antibacterial activity of chitosan/collagen membranes containing red propolis extract |
Autor(es): | Loureiro, K. Cavalcante Barbosa, T. Carvalho Nery, M. Chaud, M. Vinicius Silva, C. Ferreira da Andrade, L. Nalone Corrêa, C. Bani Jaguer, A. Souto, Eliana B. Severino, P. |
Data: | Mar-2020 |
Editora: | Avoxa |
Revista: | Pharmazie |
Citação: | Loureiro, K. Cavalcante; Barbosa, T. Carvalho; Nery, M.; Chaud, M. Vinicius; da Silva, C. Ferreira; Andrade, L. Nalone; Corrêa, C. Bani; Jaguer, A.; Padilha, F. Ferreira; Cardoso, J. Cordeiro; Souto, Eliana; Severino, P., Antibacterial activity of chitosan/collagen membranes containing red propolis extract. Die Pharmazie - An International Journal of Pharmaceutical Sciences, 75(2-3), 75-81, 2020 |
Resumo(s): | In this study we developed a mucoadhesive polymeric membrane wound dressing incorporating red propolis extract (HERP). Membranes were made using a casting method employing collagen, chitosan, polyethylene glycol (15, 20, and 30v%), and hydroethanolic extract of EtOH-H2O 70v% 30v% (v/v) of HERP (0.5, 1.0, and 1.5%). Membranes were extensively characterized to assess the thickness, pH, morphology using Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), mechanical properties, swelling, in vitro mucoadhesion, cytotoxicity, and minimum inhibitory concentration (MIC). Assessment of the thickness and mechanical properties of the membranes containing HERP revealed that the most significant thickness obtained was 40.7 m; thermal analysis suggests suggesting the hydrogen bonds between hydroxyl groups of isoflavones and the free amine present in the region of chitosan. Cell viability decreased as the amount of HERP increased. Finally, the MICs were 7.8 and 1.9 g.mL1 for Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853, respectively. These results were suggesting that the 0.5 % HERP membrane has the potential for future studies for wound application. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/70945 |
DOI: | 10.1691/ph.2020.9050 |
ISSN: | 0031-7144 |
Versão da editora: | https://www.ingentaconnect.com/content/govi/pharmaz/2020/00000075/f0020002/art00005 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54332_1.pdf | 1,01 MB | Adobe PDF | Ver/Abrir |