Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/71133
Título: | Nanoemulsions for enhancement of curcumin bioavailability and their safety evaluation: effect of emulsifier type |
Autor(es): | Gonçalves, Raquel Filipa Silva Martins, Joana T. Abrunhosa, Luís Vicente, A. A. Pinheiro, A. C. |
Palavras-chave: | nanoemulsions lecithin rhamnolipids Tween® 80 In vitro static digestion cytotoxicity Tween(®) 80 |
Data: | 2021 |
Editora: | MDPI |
Revista: | Nanomaterials |
Citação: | Gonçalves, Raquel F. S.; Martins, Joana T.; Abrunhosa, Luís; Vicente, António A.; Pinheiro, Ana Cristina, Nanoemulsions for enhancement of curcumin bioavailability and their safety evaluation: effect of emulsifier type. Nanomaterials, 11(3), 815, 2021 |
Resumo(s): | This work aimed at evaluating the effects of different emulsifiers on curcumin-loaded nanoemulsions behavior during digestion, its safety and absorption, to develop nanoemulsions that provide safety and improved curcumin functionality. Nanoemulsions (NEs) were produced using two bio-based (lecithin (LEC) and rhamnolipids (RHAM)) and one synthetic (Tween®80 (TWE)) emulsifier at similar concentrations. Different NEs were subjected to in vitro digestion. The cytotoxicity and permeability tests were performed in Caco-2 cells. NE_TWE were stable during all phases of in vitro digestion, whereas NE_LEC and NE_RHAM were found to be unstable from the gastric phase. NE_TWE showed 100% of free fatty acids released, followed by NE_RHAM and NE_LEC. Curcumins bioaccessibility and stability increased in the following order: NE_LEC > NE_RHAM > NE_TWE. NE_LEC and NE_TWE did not show cytotoxic effects in any of the concentrations tested, while NE_RHAM presented high cytotoxicity in all concentrations tested. The apparent permeability coefficients were determined for NE_LEC and NE_TWE; however, the results were not statistically different. These results showed that the emulsifier used has a high impact on nanoemulsions behavior under the digestion process and on their cytotoxicity. This work contributed to the state-of-the-arts progress on the development of safer curcumin delivery systems with improved functionality, particularly regarding the proper selection of ingredients to produce said systems. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/71133 |
DOI: | 10.3390/nano11030815 |
ISSN: | 20794991 |
Versão da editora: | https://www.mdpi.com/2079-4991/11/3/815 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54354_1.pdf | 2,64 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons