Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/72841
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Campo DC | Valor | Idioma |
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dc.contributor.author | Oliveira-Pinto, Sofia | por |
dc.contributor.author | Pontes, Olivia | por |
dc.contributor.author | Lopes, Diogo | por |
dc.contributor.author | Marques, Maria Belém Sousa Sampaio | por |
dc.contributor.author | Costa, Marta D. | por |
dc.contributor.author | Carvalho, Luisa | por |
dc.contributor.author | Goncalves, Celine S. | por |
dc.contributor.author | Costa, Bruno Marques | por |
dc.contributor.author | Maciel, P. | por |
dc.contributor.author | Ludovico, Paula | por |
dc.contributor.author | Baltazar, Fátima | por |
dc.contributor.author | Proença, M. Fernanda R. P. | por |
dc.contributor.author | Costa, Marta | por |
dc.date.accessioned | 2021-05-25T14:24:09Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Oliveira-Pinto, S., Pontes, O., Lopes, D., Sampaio-Marques, B., Costa, M. D., Carvalho, L., . . . Costa, M. (2020). Unravelling the anticancer potential of functionalized chromeno[2,3-b]pyridines for breast cancer treatment. Bioorganic Chemistry, 100, 103942. doi: https://doi.org/10.1016/j.bioorg.2020.103942 | por |
dc.identifier.issn | 0045-2068 | por |
dc.identifier.uri | https://hdl.handle.net/1822/72841 | - |
dc.description.abstract | A selection of new chromeno[2,3-b]pyridines was prepared from chromenylacrylonitriles and N-substituted piperazines, using a novel and efficient synthetic procedure. The compounds were tested for their anticancer activity using breast cancer cell lines MCF-7, Hs578t and MDA-MB-231 and the non-neoplastic cell line MCF-10A for toxicity evaluation. In general, compounds showed higher activity towards the luminal breast cancer subtype (MCF-7), competitive with the reference compound Doxorubicin. The in vivo toxicity assay using C. elegans demonstrated a safe profile for the most active compounds. Chromene 3f revealed a promising drug profile, inhibiting cell growth and proliferation, inducing cell cycle arrest in G /M phase, apoptosis and microtubule destabilization. The new compounds presented exciting bioactive features and may be used as lead compounds in cancer related drug discovery. 2 | por |
dc.description.sponsorship | We acknowledge the financial support from University of Minho, Fundacao para a Ciencia e a Tecnologia (FCT) and FEDERCOMPETE for financial support through Centro de Quimica (UID/QUI/00686/2013 and UID/QUI/0686/2016), for the PhD grant awarded to Olivia Pontes (SFRH/BD/128850/2017) Research grant from Liga Portuguesa Contra o Cancro to Sofia Oliveira-Pinto. The NMR spectrometer Bruker Avance III 400 is part of the National NMR Network (RNRMN) and was purchased within the framework of the National Program for Scientific Reequipment, contract REDE/1517/RMN/2005 with funds from POCI 2010 (FEDER) and FCT. This work was also developed under the project NORTE-01-0145-FEDER-000013, by the Northern Portugal Regional Operational Program (NORTE 2020), through the European Regional Development Fund (FEDER) and the Competitiveness Factors Operational Program (COMPETE) and by National funds, through the Foundation for Science and Technology (ref. POCI-01-0145-FEDER-007038). | por |
dc.language.iso | eng | por |
dc.publisher | Academic Press | por |
dc.relation | UID/QUI/00686/2013 | por |
dc.relation | UID/QUI/0686/2016 | por |
dc.relation | SFRH/BD/128850/2017 | por |
dc.rights | restrictedAccess | por |
dc.subject | Anticancer activity | por |
dc.subject | Breast cancer | por |
dc.subject | C. elegans | por |
dc.subject | Chromeno[2,3-b]pyridine | por |
dc.title | Unravelling the anticancer potential of functionalized chromeno[2,3-b ] pyridines for breast cancer treatment | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://linkinghub.elsevier.com/retrieve/pii/S0045206820308920 | por |
oaire.citationVolume | 100 | por |
dc.date.updated | 2021-05-20T22:42:37Z | - |
dc.identifier.doi | 10.1016/j.bioorg.2020.103942 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 32450388 | - |
dc.subject.fos | Ciências Médicas::Ciências da Saúde | por |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
dc.subject.wos | Science & Technology | - |
sdum.export.identifier | 10750 | - |
sdum.journal | Bioorganic Chemistry | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
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1-s2.0-S0045206820308920-main.pdf Acesso restrito! | 3,75 MB | Adobe PDF | Ver/Abrir |