Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/75108
Título: | Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities |
Autor(es): | Guedes, Marta Vieira, Sara Filipa Fontoura Reis, R. L. Ferreira, Helena Susana Costa Machado Neves, N. M. |
Palavras-chave: | Anti-inflammatory activity Antioxidant activity Fishroesomes Inflammatory diseases Sardine roe |
Data: | Abr-2021 |
Editora: | Elsevier 1 |
Revista: | Biomedicine & Pharmacotherapy |
Citação: | Guedes M., Vieira S. F., Reis R. L., Ferreira H., Neves N. M. Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities, Biomedicine & Pharmacotherapy, Vol. 140, pp. 111680, doi:10.1016/j.biopha.2021.111680, 2021 |
Resumo(s): | The great diversity of marine habitats and organisms renders them a high-value source to find/develop novel drugs and formulations. Therefore, herein, sardine (Sardina pilchardus) roe was used as a lipidic source to produce liposomes. This fish product presents high nutritional value, being its lipidic content associated with important health benefits. Consequently, it can be advantageously used to produce therapeutically active delivery devices. Roe lipids were extracted using the Matyash method. After lipid film hydration and extrusion, sardine roe-derived large unilamellar liposomes (LUVs), designated as fishroesomes, presented a size of â 330 nm and a significant negative surface charge (â - 27 mV). Radical scavenging assays demonstrated that fishroesomes efficiently neutralized peroxyl, hydroxyl and nitric oxide radicals. Moreover, fishroesomes significantly reduced the expression of pro-inflammatory cytokines and chemokines by LPS-stimulated macrophages at non-toxic concentrations for L929 and THP-1 cells. Consequently, the developed liposomes exhibit unique properties as bioactive drug carriers for inflammatory diseases treatment. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/75108 |
DOI: | 10.1016/j.biopha.2021.111680 |
ISSN: | 0753-3322 |
Versão da editora: | https://pubmed.ncbi.nlm.nih.gov/34020247/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20669-fishroesomes-carriers-antioxidant-and.pdf | 10,05 MB | Adobe PDF | Ver/Abrir |