Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/75601
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Baldim, Iara | por |
dc.contributor.author | Oliveira, Andressa M. | por |
dc.contributor.author | Souto, Eliana Maria Barbosa | por |
dc.contributor.author | Oliveira, Wanderley P. | por |
dc.date.accessioned | 2022-01-20T09:51:52Z | - |
dc.date.available | 2022-01-20T09:51:52Z | - |
dc.date.issued | 2022-01-10 | - |
dc.identifier.citation | Baldim, Iara; Oliveira, Andressa M.; Souto, Eliana B.; Oliveira, Wanderley P., Cyclodextrins-in-liposomes: a promising delivery system for Lippia sidoides and Syzygium aromaticum essential oils. Life, 12(1), 95, 2022 | por |
dc.identifier.issn | 0024-3019 | por |
dc.identifier.uri | https://hdl.handle.net/1822/75601 | - |
dc.description.abstract | Biological activity of essential oils (EOs) has been extensively reported; however, their low aqueous solubility, high photosensitivity, and volatility compromise a broad industrial use of these compounds. To overcome these limitations, we proposed a nanoencapsulation approach to protect EOs, that aims to increase their stability and modulate their release profile. In this study, drug-in-cyclodextrin-in-liposomes encapsulating two essential oils (Lippia sidoides and Syzygium aromaticum) and their respective major compounds (thymol and eugenol) were produced by ethanol injection and freeze-dried to form proliposomes and further physicochemically characterized. Liposomes showed high physical stability over one month of storage at 4 °C, with slight changes in the mean size, polydispersity index (PDI), and zeta potential. Reconstituted proliposomes showed a mean size between 350 and 3300 nm, PDI from 0.29 to 0.41, and zeta potential between −22 and −26 mV. Differential scanning calorimetry and X-ray diffraction of proliposomes revealed a less-ordered crystalline structure, leading to high retention of the major bioactive compounds (between 73% and 93% for eugenol, and 74% and 84% for thymol). This work highlights the advantages of using drug-in-cyclodextrin-in-liposomes as delivery systems to retain volatile compounds, increasing their physicochemical stability and their promising potential to be utilized as carriers in products in the pharmaceutical, food, and cosmetic industries. | por |
dc.description.sponsorship | Authors received funding from The State of São Paulo Research Foundation (FAPESP) for sponsorship of the project No. 2018/26069-0; from the Coordination of Superior Level Staff Improvement (CAPES) for the fellowship of the first author. The authors also acknowledge the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) for national funds co-financed by FEDER, under the Partnership Agreement PT2020 for the granted project UIDB/04469/2020 (strategic fund). | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | por |
dc.relation | UIDB/04469/2020 | por |
dc.rights | openAccess | por |
dc.subject | Proliposomes | por |
dc.subject | Cyclodextrins | por |
dc.subject | Thymol | por |
dc.subject | Eugenol | por |
dc.subject | Lippia sidoides | por |
dc.subject | Syzygium aromaticum | por |
dc.title | Cyclodextrins-in-liposomes: a promising delivery system for Lippia sidoides and Syzygium aromaticum essential oils | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/journal/life | por |
dc.comments | CEB55171 | por |
oaire.citationStartPage | 95 | por |
oaire.citationIssue | 1 | por |
oaire.citationConferencePlace | Switzerland | - |
oaire.citationVolume | 12 | por |
dc.date.updated | 2022-01-19T22:27:55Z | - |
dc.identifier.doi | 10.3390/life12010095 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Life | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_55171_1.pdf | 2,91 MB | Adobe PDF | Ver/Abrir |