Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/76243
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Fernandes, Ana R. | por |
dc.contributor.author | Santos, Tiago dos | por |
dc.contributor.author | Granja, Pedro L. | por |
dc.contributor.author | Sanchez-Lopez, Elena | por |
dc.contributor.author | Garcia, Maria L. | por |
dc.contributor.author | Silva, Amelia M. | por |
dc.contributor.author | Souto, Eliana B. | por |
dc.date.accessioned | 2022-03-01T17:27:10Z | - |
dc.date.issued | 2022-04-05 | - |
dc.identifier.citation | Fernandes, Ana R.; Santos, Tiago dos; Granja, Pedro L.; Sanchez-Lopez, Elena; Garcia, Maria L.; Silva, Amelia M.; Souto, Eliana B., Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cationic nanoemulsions in retinal pigment epithelial cells under oxidative stress. International Journal of Pharmaceutics, 617(121615), 2022 | por |
dc.identifier.issn | 0378-5173 | por |
dc.identifier.uri | https://hdl.handle.net/1822/76243 | - |
dc.description.abstract | Age-related macular degeneration (AMD) is defined as a degenerative, progressive and multifactorial disorder that affects the macula with a complex etiology. The retinal pigment epithelium is a monolayer of cells that has the function to separate the surface of the choroid from the neural retina that is involved in the signal transduction leading to vision. The blood-aqueous barrier and the blood retinal barrier limit the permeation of drugs into the retina and thereby reducing their efficacy. Triamcinolone acetonide (TA) is widely used as anti-inflammatory and immunomodulatory drug that promotes the inhibition of the inflammatory processes. The factors that stimulate or inhibit angiogenesis in AMD create a local balance that is responsible for the growth of sub-retinal neovascularization. In AMD, the main angiogenic stimulus is the vascular endothelial growth factor (VEGF). In this work, nanoemulsions with cationic surfactants (mono- and dicationic DABCO and quinuclidine) were produced to deliver TA, and were found to reduce the production of tumor necrosis factor alpha (TNF-), which stimulates the choroidal neovascularization development by upregulating the VEGF production, and consequently decreased the VEGF levels. Our results support the potential use of mono- and dicationic DABCO and quinuclidine-based cationic nanoemulsions for the delivery of TA in the treatment of AMD. | por |
dc.description.sponsorship | This work was funded by the Portuguese Science and Technology Foundation (FCT) from the Ministry of Science and Technology (MCTES) for the scholarship SFRH/BD/130555/2017 granted to A. R. Fernandes, and for the projects UIDB/04469/2020 (CEB strategic fund) and UIDB/04033/2020 (CITAB), co-funded by European Funds (PRODER/COMPETE) and FEDER, under the Partnership Agreement PT2020. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | SFRH/BD/130555/2017 | por |
dc.relation | UIDB/04033/2020 | por |
dc.rights | restrictedAccess | por |
dc.subject | Cationic nanoemulsions | por |
dc.subject | Triamcinolone acetonide | por |
dc.subject | Vascular Endothelial Growth Factor | por |
dc.subject | Tumor Necrosis Factor alpha | por |
dc.subject | Choroidal neovascularization | por |
dc.subject | Tumor Necrosis Factor alpha, Choroidal neovascularization | por |
dc.title | Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cationic nanoemulsions in retinal pigment epithelial cells under oxidative stress | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.elsevier.com/locate/issn/03785173 | por |
dc.comments | CEB55316 | por |
oaire.citationIssue | 121615 | por |
oaire.citationConferencePlace | Netherlands | - |
oaire.citationVolume | 617 | por |
dc.date.updated | 2022-03-01T17:03:18Z | - |
dc.identifier.doi | 10.1016/j.ijpharm.2022.121615 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 35217072 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | International Journal of Pharmaceutics | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_55316_1.pdf Acesso restrito! | 891,01 kB | Adobe PDF | Ver/Abrir |