Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/78272
Título: | Oxidized cashew gum scaffolds for tissue engineering |
Autor(es): | Maciel, Jeanny S. Azevedo, Sara Correia, Clara R. Costa, Ana M. S. Costa, Rui Filipe Ramos Magalhães, Francisco A. Monteiro, Aliny Abreu de Costa, José Francisco Gomes Paula, Regina C. M de Feitosa, Judith P.A. Mano, J. F. |
Palavras-chave: | Cashew gum Gelatin Natural materials lyophilized sponges periodate oxidation tissue engineering |
Data: | Jan-2019 |
Editora: | Wiley |
Revista: | Macromolecular Materials and Engineering |
Citação: | Maciel J. S., Azevedo S., Correia C. R., Costa A. M. S., Costa R. R., Magalhães F. A., Monteiro A. A. S., Costa J. F. G., De Paula R. C. M., Feitosa J. P. A., Mano J. F. Oxidized Cashew Gum Scaffolds for Tissue Engineering, Macromolecular Materials And Engineering, Vol. 304, Issue 3, pp. 1800574, doi:10.1002/mame.201800574, 2019 |
Resumo(s): | In the last few years, several strategies have been proposed to fabricate scaffolds for tissue engineering (TE) applications; however, they are based on harsh and timeâ consuming techniques. The choice for natural polymers such as cashew gum (CG) allows to circumvent the demands of biocompatibility and degradability of TE systems. In this work, CG, a polysaccharide derived from Anacardium occidentale trees, is functionalized with aldehyde groups through periodate oxidation. The resultant oxidized cashew gum (CGO) is mixed with gelatin (GE) to yield a covalently crosslinked hydrogel. CGO/GE sponges are obtained by employing a freezeâ drying methodology to the previously obtained hydrogels. The mechanical properties, swelling ability, and porosity of the GE/CGO sponges are tuned by using CGO with different degrees of oxidation. The resultant sponges can maintain high levels of water absorption and recover their initial mechanical properties after cyclic compression. Moreover, these porous and mechanically robust devices can support the adhesion and proliferation of cells, which can envision their application for the regeneration of soft tissues. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/78272 |
DOI: | 10.1002/mame.201800574 |
ISSN: | 1439-2054 |
Versão da editora: | https://onlinelibrary.wiley.com/doi/abs/10.1002/mame.201800574 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19774-mame.201800574.pdf Acesso restrito! | 4,1 MB | Adobe PDF | Ver/Abrir |