Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/80177
Título: | Development of an innovative flexible paper-based methanol fuel cell (PB-DMFC) sensing platform application to sarcosine detection |
Autor(es): | Carneiro, Liliana Pinto, Alexandra M. F. R. Sales, M. G. F. |
Palavras-chave: | Paper-based methanol fuel cell Sensing platform Molecularly imprinted polymer Sarcosine Point of care Cancer biomarker |
Data: | 15-Jan-2023 |
Editora: | Elsevier 1 |
Revista: | Chemical Engineering Journal |
Citação: | Carneiro, Liliana; Pinto, Alexandra M. F. R.; Sales, M. G. F., Development of an innovative flexible paper-based methanol fuel cell (PB-DMFC) sensing platform application to sarcosine detection. Chemical Engineering Journal, 452, Part 4(139563), 2023 |
Resumo(s): | This work describes for the first time a paper-based direct methanol fuel cell platform (PB-DMFC) that functions as an energy source and biosensor, assembled on a simple paper substrate for point-of-care (POC) applications, targeting sarcosine as proof-of-concept. Specifically, a methanol fuel cell strip was developed from a square of Whatman paper, acting as substrate. The paper strip was treated with an impermeable agent (paraffin solution) and supported all fuel cell device components, including the electrolyte (Nafion®), anode electrode (carbon black Pt/Ru), cathode electrode (carbon black Pt), and current collectors (silver edges). All the described components formed a flexible single layer that operated in a completely passive mode by adding few microliters of a methanol solution on the anode side and by using atmospheric oxygen on the cathode side. The obtained platform had a stable electrical signal with an average OCV value of 0.45-0.55V and a maximum power density of 20-50µW/cm2, depending on the methanol concentration used (0.5M 2M). A sensing layer was built in situ on the anode electrode by electropolymerization of a solution of 3,4-ethylenedioxythiophene (EDOT) and pyrrole (Py) as monomers. The obtained PB-DMFC/biosensor was calibrated at room temperature in buffer and healthy human urine and showed linear responses from 1.0×10-7 to 1.0×10-3M with a detection limit of 6.6×10-8M. Selectivity studies evidenced signals changing within 1-10%, both in positive and negative directions. Results evidenced good reproducibility. Overall, the obtained results demonstrate a self-sufficient biosensor for the detection of sarcosine consisting of an innovative paper-based methanol fuel cell strip. This concept can open new horizons for massification of biosensors even in places with energy shortage. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/80177 |
DOI: | 10.1016/j.cej.2022.139563 |
ISSN: | 1385-8947 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S1385894722050422 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_55790_1.pdf | 3,85 MB | Adobe PDF | Ver/Abrir |