Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/80672
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Campo DC | Valor | Idioma |
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dc.contributor.author | Costa, André | por |
dc.contributor.author | Luís, Salomé | por |
dc.contributor.author | Noro, Jennifer Martins | por |
dc.contributor.author | Silva, Sónia Carina | por |
dc.contributor.author | Silva, C. | por |
dc.contributor.author | Ribeiro, Artur | por |
dc.date.accessioned | 2022-11-15T09:51:24Z | - |
dc.date.available | 2022-11-15T09:51:24Z | - |
dc.date.issued | 2022-11-13 | - |
dc.identifier.citation | Costa, A.F.; Luís, S.; Noro, J.; Silva, S.; Silva, C.; Ribeiro, A. Therapeutic Textiles Functionalized with Keratin-Based Particles Encapsulating Terbinafine for the Treatment of Onychomycosis. Int. J. Mol. Sci. 2022, 23, 13999. https://doi.org/10.3390/ijms232213999 | por |
dc.identifier.isbn | 1424-6783 | - |
dc.identifier.issn | 1661-6596 | por |
dc.identifier.uri | https://hdl.handle.net/1822/80672 | - |
dc.description | The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/ijms232213999/s1. | por |
dc.description.abstract | Onychomycosis is the most common nail fungal infection worldwide. There are several therapy options available for onychomycosis, such as oral antifungals, topicals, and physical treatments. Terbinafine is in the frontline for the treatment of onychomycosis; however, several adverse effects are associated to its oral administration. In this work, innovative keratin-based carriers encapsulating terbinafine were designed to overcome the drawbacks related to the use this drug. Therapeutic textiles functionalized with keratin-based particles (100% keratin; 80% keratin/20% keratin-PEG) encapsulating terbinafine were developed. The controlled release of terbinafine from the functionalized textiles was evaluated against different mimetic biologic solutions (PBS buffer—pH=7.4, micellar solution and acidic sweat solution—pH=4.3). The modification of keratin with polyethylene glycol (PEG) moieties favored the release of terbinafine at the end of 48 h for all the solution conditions. When the activity of functionalized textiles was tested against Trichophyton rubrum, a differentiated inhibition was observed. Textiles functionalized with 80% keratin/20% keratin-PEG encapsulating terbinafine showed a 2-fold inhibition halo compared with the textiles containing 100% keratin-encapsulating terbinafine. No activity was observed for the textiles functionalized with keratin-based particles without terbinafine. The systems herein developed revealed therapeutic potential towards nail fungal infections, taking advantage of keratin-based particles affinity to keratin structures and of the keratinase activity of T. rubrum. | por |
dc.description.sponsorship | This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit, and by LABBELS – Associate Laboratory in Biotechnology, Bioengineering and Microelectromechanical Systems, LA/P/0029/2020. AR thanks to Portuguese Foundation for Science and Technology (FCT) for is con tract under the CEEC-Individual—4th Edition with the reference 2021.02803.CEECIND. | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04469%2F2020/PT | por |
dc.relation | 2021.02803.CEECIND | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | keratin-based particles | por |
dc.subject | terbinafine | por |
dc.subject | therapeutic textiles | por |
dc.title | Therapeutic textiles functionalized with keratin-based particles encapsulating terbinafine for the treatment of onychomycosis | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/23/22/13999 | por |
dc.comments | CEB55883 | por |
oaire.citationIssue | 22 | por |
oaire.citationConferencePlace | Switzerland | - |
oaire.citationVolume | 23 | por |
dc.date.updated | 2022-11-15T09:25:33Z | - |
dc.identifier.eissn | 1422-0067 | por |
dc.identifier.doi | 10.3390/ijms232213999 | por |
dc.identifier.pmid | 36430474 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | International Journal of Molecular Sciences | por |
oaire.version | VoR | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_55883_1.pdf | 1,13 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons