Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/81744
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Silva, Cláudia A. | por |
dc.contributor.author | Fernandes, Margarida M. | por |
dc.contributor.author | Ribeiro, Clarisse Marta Oliveira | por |
dc.contributor.author | Lanceros-Méndez, S. | por |
dc.date.accessioned | 2023-01-11T16:45:53Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 0927-7765 | por |
dc.identifier.uri | https://hdl.handle.net/1822/81744 | - |
dc.description.abstract | The incidence of bone disorders worldwide is increasing and new and more effective strategies for bone repair are needed. The most common strategy used for cell regeneration relies in biochemical stimulation while biophysical stimulation using mechanical, and electrical cues is a promising, however, still under-investigated field. This work reports on the development of piezoelectric 2D and 3D porous scaffolds for bone tissue regeneration strategies. While the porous scaffolds mimic the bone’s structure, the piezoelectric activity of the scaffolds mimics the bone mechano-electric microenvironment. The piezoelectric activity is related to the electroactive β-phase of poly(vinylidene fluoride) (PVDF) in the scaffolds and was dynamically stimulated by cell culture in a custom-made mechanical bioreactor. These two factors combined provide an effective biomimetic environment for the proliferation of osteoblasts. The electromechanically-responsive scaffolds are found to promote the enhancement of proliferation rate of MC3T3-E1 osteoblastic cells in about 20% as well as an improved adhesion and proliferation over the materials, mainly when dynamically stimulated. These results prove that local piezoelectric effect, as the one existing in bone tissue, allows effective cell proliferation, which could be further translated in more efficient strategies for bone tissue regeneration. | eng |
dc.description.sponsorship | This work has been supported by FCT – Fundação para a Ciência e Tecnologia (FCT) under the scope of the strategic funding of UIDB/00319/2020, UID/FIS/04650/2020 and UIDB/04469/2020 units, and project PTDC/BTM-MAT/28237/2017. The authors also thank FCT for financial support under grants SFRH/BPD/121464/2016 (MMF) and 2020.04163.CEECIND (CR). Finally, the authors acknowledge funding by Spanish State Research Agency (AEI) and the European Regional Development Fund (ERFD) through the project PID2019-106099RB-C43/AEI/10.13039/501100011033 and from the Basque Government Industry Departments under the ELKARTEK program. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00319%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04650%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04469%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-MAT%2F28237%2F2017/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBPD%2F121464%2F2016/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/CEEC IND 3ed/2020.04163.CEECIND%2FCP1600%2FCT0019/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | 2D scaffolds | por |
dc.subject | 3D scaffolds | por |
dc.subject | PVDF | por |
dc.subject | Piezoelectric | por |
dc.subject | Mechano-electric effect | por |
dc.subject | Bone tissue engineering | por |
dc.title | Two- and three-dimensional piezoelectric scaffolds for bone tissue engineering | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0927776522003915 | por |
oaire.citationVolume | 218 | por |
dc.identifier.eissn | 1873-4367 | por |
dc.identifier.doi | 10.1016/j.colsurfb.2022.112708 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 35985127 | por |
dc.subject.fos | Engenharia e Tecnologia::Engenharia dos Materiais | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Colloids and Surfaces B: Biointerfaces | por |
Aparece nas coleções: | CDF - FCD - Artigos/Papers (with refereeing) |
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21.pdf Acesso restrito! | 928,87 kB | Adobe PDF | Ver/Abrir |