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https://hdl.handle.net/1822/83065
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Campo DC | Valor | Idioma |
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dc.contributor.author | Sousa, Mariana | por |
dc.contributor.author | Afonso, Ana Cristina | por |
dc.contributor.author | Teixeira, Lília Soares | por |
dc.contributor.author | Borges, Anabela | por |
dc.contributor.author | Saavedra, Maria José | por |
dc.contributor.author | Simões, Lúcia Chaves | por |
dc.contributor.author | Simões, Manuel | por |
dc.date.accessioned | 2023-03-07T10:30:53Z | - |
dc.date.available | 2023-03-07T10:30:53Z | - |
dc.date.issued | 2023-02-06 | - |
dc.identifier.citation | Sousa, Mariana; Afonso, Ana Cristina; Teixeira, Lília Soares; Borges, Anabela; Saavedra, Maria José; Simões, Lúcia C.; Simões, Manuel, Hydrocinnamic acid and perillyl alcohol potentiate the action of antibiotics against Escherichia coli. Antibiotics, 12(2), 360, 2023 | por |
dc.identifier.issn | 2079-6382 | por |
dc.identifier.uri | https://hdl.handle.net/1822/83065 | - |
dc.description.abstract | Aquaculture requires new, economical, and eco-friendly protein sources to replace traditional fisheries and plant ingredients. Using agriculture by-products as protein sources would reduce land-based feed production pressure and waste production, promoting a circular economy and sustainable aquaculture. Distillers dried grains with solubles (DDGS) is the main by-product of bioethanol production. Corn DDGS has a high protein level, but its high fiber content limits its use as a feed ingredient, particularly for carnivorous fish. Solid-state fermentation (SSF) uses lignocellulosic-rich substrates, such as DDGS, for microbial growth in the near absence of water, promoting enzyme production that degrades the lignocellulosic matrix, increasing free reducing sugars, protein, and antioxidant levels of the substrate. In the present work, the SSF of corn DDGS with Aspergillus carbonarius, A. ibericus, and A. uvarum was tested. Then, the digestibility of the most promising fermented DDGS (in terms of upgraded nutritional composition) was tested by including it in a reference diet (70% of a reference diet; 48% crude protein; 15% crude lipids) for European seabass (Dicentrarchus labrax) juveniles (171 g averaged weight; trial duration of 52 days). Among the fungi tested, Aspergillus ibericus led a generally higher upgrading of the DDGS nutritional composition, leading to a high amount of protein (from 42.7 to 49.7 g N/kg DM), phenolic compounds (1.49 to 4.86 mg/g caffeic acid equivalents), free sugars (9.5 to 31.9 mg/g), and enzyme production (45 U/g and 68 U/g of cellulase and xylanase, respectively), and a high reduction in acid detergent fiber and neutral detergent fiber content (up to 29 and 43%, respectively). Compared to the unfermented DDGS, fermented DDGS presented increased protein, lipids, starch, and energy digestibility, while phosphorous digestibility was similar. Compared to the reference diet, dietary inclusion of unfermented or fermented DDGS increased trypsin and chymotrypsin activities. The activity of digestive enzymes was not affected by the inclusion of fermented DDGS, except for amylase activity, which was lower with the fermented DDGS than with the unfermented DDGS diet. In conclusion, SSF of DDGS enhanced its nutritional value, increasing DDGS digestibility when included in diets for European seabass juveniles. | por |
dc.description.sponsorship | This research was funded by LA/P/0045/2020 (ALiCE), UIDB/00511/2020, and UIDP/00511/2020 (LEPABE), funded by national funds through FCT/MCTES (PIDDAC); UIDB/04469/2020 (CEB) and by LABBELS—Associate Laboratory in Biotechnology, Bioengineer ing and Microelectromechanical Systems., LA/P/0029/2020; UIDB/AGR/04033/2020 (CITAB); Germirrad-POCI-01-0247-FEDER-072237, funded by FEDER funds through COMPETE2020–Programa Operacional Competitividade e Internacionalização (POCI) and by national funds (PIDDAC) through FCT/MCTES; and the FCT grant (2020.04773.BD). Anabela Borges thanks the FCT for the financial support of her work contract through the Scientific Employment Stimulus—Individual Call—[CEECIND/00823/2021]. | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.relation | LA/P/0045/2020 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00511%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00511%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04469%2F2020/PT | por |
dc.relation | LA/P/0029/2020 | por |
dc.relation | UIDB/AGR/04033/2020 | por |
dc.relation | POCI-01-0247-FEDER-072237 | por |
dc.relation | CEECIND/00823/2021 | por |
dc.rights | openAccess | por |
dc.subject | Antibiotic recalcitrance | por |
dc.subject | Plant-based natural product | por |
dc.subject | Perillyl alcohol | por |
dc.subject | Hydrocinnamic acid | por |
dc.subject | Combinatorial therapy | por |
dc.subject | Phytochemical-antibiotic interaction | por |
dc.title | Hydrocinnamic acid and perillyl alcohol potentiate the action of antibiotics against Escherichia coli | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2079-6382/12/2/360 | por |
dc.comments | CEB56099 | por |
oaire.citationStartPage | 360 | por |
oaire.citationIssue | 2 | por |
oaire.citationVolume | 12 | por |
dc.date.updated | 2023-03-06T15:05:12Z | - |
dc.identifier.eissn | 2079-6382 | por |
dc.identifier.doi | 10.3390/antibiotics12020360 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Antibiotics | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_56099_1.pdf | 2,93 MB | Adobe PDF | Ver/Abrir |