Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/85420
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Escobar, Ane | por |
dc.contributor.author | Serafin, Aleksandra | por |
dc.contributor.author | Carvalho, Mariana Rodrigues | por |
dc.contributor.author | Culebras, Mario | por |
dc.contributor.author | Cantarero, Andres | por |
dc.contributor.author | Beaucamp, Anne | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Oliveira, Joaquim M. | por |
dc.contributor.author | Collins, Maurice N. | por |
dc.date.accessioned | 2023-07-06T16:10:06Z | - |
dc.date.available | 2023-07-06T16:10:06Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.citation | Escobar A., Serafin A., Carvalho M. R., Culebras M., Cantarero A., Beaucamp A., Reis R. L., Oliveira J. M., Collins M. N. Electroconductive poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticle-loaded silk fibroin biocomposite conduits for peripheral nerve regeneration, Advanced Composites and Hybrid Materials , doi:10.1007/s42114-023-00689-2, 2023 | por |
dc.identifier.issn | 2522-0128 | por |
dc.identifier.uri | https://hdl.handle.net/1822/85420 | - |
dc.description.abstract | Peripheral nerve injury (PNI) often clinically relies on the use of nerve grafts taken from the patient to establish a therapeutic effect, though secondary site of injury and morbidity have prompted the medical community to find alternative solutions. A new trend in the development of biomaterials arises in the form of electro-conductive biomaterials, especially for electrically active tissues such as the peripheral nerves. In this work, novel poly(3,4-ethylenedioxythiophene) PEDOT nanoparticles (PEDOT NPs) were synthetized via the mini-emulsion method and were combined with silk fibroin (SF) to create conduits for PNI repair. The synthesized PEDOT NPs-loaded SF conduits showed optimal properties for peripheral nerve substitution from the physico-chemical and biological point of view. They displayed excellent mechanical and conductivity performance with the tensile moduli reaching 6.61â ±â 0.55 MPa and the conduits reaching 5.4 · 10â 4 S cmâ 1, respectively. The conduits did not possess apatite-forming capacity, which were resistant to bending occlusions for angles up to 50° and to suturing. The developed conduits are promising as a novel biomaterial for applications in peripheral nerve regeneration; in vitro experiments showed that they did not allow BJ fibroblast infiltration, avoiding scar tissue formation in the lumen, and they did not show any toxic effect for Schwann cells. | por |
dc.description.sponsorship | Open access funding provided by FCT|FCCN (b-on). This study received fnancial support from the Portuguese Foundation for Science and Technology under the distinction attributed to JMO (IF/01285/2015) and the project NanOptoNerv (ref. PTDC/NANMAT/29936/2017), the European Commission and FEDER program under the JUSTHera project (NORTE-01-0145-FEDER-000055) and the 0624_2IQBIONEURO_6_E project (Inter-regional cooperation program VA Spain-Portugal POCTEP 2014–2020), and the Irish Research Council under EPSPG/2020/78 and New Foundations Grant 2019. | por |
dc.language.iso | eng | por |
dc.publisher | Springer | por |
dc.relation | info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01285%2F2015%2FCP1294%2FCT0008/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FNAN-MAT%2F29936%2F2017/PT | por |
dc.rights | openAccess | por |
dc.subject | Conductivity | por |
dc.subject | Electroconductive polymers | por |
dc.subject | Nanoparticles | por |
dc.subject | Nerve guidance conduits | por |
dc.subject | Peripheral Nerve Regeneration | por |
dc.title | Electroconductive poly(3,4‑ethylenedioxythiophene) (PEDOT) nanoparticle‑loaded silk fibroin biocomposite conduits for peripheral nerve regeneration | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s42114-023-00689-2 | por |
dc.comments | http://3bs.uminho.pt/node/20945 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 18 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 6 | por |
dc.date.updated | 2023-07-06T09:03:43Z | - |
dc.identifier.eissn | 2522-0136 | por |
dc.identifier.doi | 10.1007/s42114-023-00689-2 | por |
sdum.journal | Advanced Composites and Hybrid Materials | por |
dc.identifier.articlenumber | 118 | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20945-anne.pdf | 4,25 MB | Adobe PDF | Ver/Abrir |