Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/86399
Título: | Fisetin derivatives exhibit enhanced anti-inflammatory activity and modulation of endoplasmic reticulum stress |
Autor(es): | Silva, Daniela Correia da Jervis, Peter John Martins, J. A. R. Valentão, Patrícia Ferreira, Paula M. T. Pereira, David M. |
Palavras-chave: | Fisetin Natural products IL-6 TNF-α IL-1β ATF4 CHOP Endoplasmic reticulum stress Inflammasome Inflammation |
Data: | 23-Jun-2023 |
Editora: | Elsevier 1 |
Revista: | International Immunopharmacology |
Citação: | Correia da Silva, D., Jervis, P. J., Martins, J. A., Valentão, P., Ferreira, P. M. T., & Pereira, D. M. (2023, June). Fisetin derivatives exhibit enhanced anti-inflammatory activity and modulation of endoplasmic reticulum stress. International Immunopharmacology. Elsevier BV. http://doi.org/10.1016/j.intimp.2023.110178 |
Resumo(s): | Fisetin (FST) is a dietary flavonol that is known to possess multiple relevant bioactivities, raising the question of its potential health benefits and even its use in novel pharmacological approaches. To attain this prospect, some limitations to this molecule, namely its poor bioavailability and solubility, must be addressed. Inflammation and endoplasmic reticulum (ER) stress are often hand in hand in the context of chronic disease. Both are activated upon perceived disturbances in homeostasis but can be deleterious when intensely or chronically activated. We have synthesized a set of FST derivatives trying to improve the biological properties of the parent molecule. These new molecules were tested along with the original compound for their ability to mitigate the activation of these signaling pathways. FST has proven to be effective against the onset of inflammation, reducing NF-κB activation, cytokine release, inflammasome activation and ROS generation, as well as decreasing the activation of the unfolded protein response (UPR). Some of the tested derivatives are also described as new caspase-1 inhibitors, being also capable of reducing pro-inflammatory cytokines and ER stress markers. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/86399 |
DOI: | 10.1016/j.intimp.2023.110178 |
ISSN: | 1567-5769 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S156757692300499X |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Fisetin derivatives.pdf | 862,59 kB | Adobe PDF | Ver/Abrir |