Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/86569
Título: | Nanostructured lipid carriers enriched hydrogels for skin topical administration of quercetin and omega-3 fatty acid |
Autor(es): | Lúcio, M. Giannino, Nicole Barreira, Sérgio Catita, José Gonçalves, Hugo Ribeiro, Artur Fernandes, Eduarda Carvalho, Isabel Pinho, Hugo Cerqueira, Fátima Biondi, Marco Lopes, Carla M. |
Palavras-chave: | quercetin omega-3 fatty acids skin topical administration nanostructured lipid carriers (NLCs) antioxidant photoprotective antimicrobial effect |
Data: | 3-Ago-2023 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Pharmaceutics |
Citação: | Lúcio, M.; Giannino, N.; Barreira, S.; Catita, J.; Gonçalves, H.; Ribeiro, A.; Fernandes, E.; Carvalho, I.; Pinho, H.; Cerqueira, F.; et al. Nanostructured Lipid Carriers Enriched Hydrogels for Skin Topical Administration of Quercetin and Omega-3 Fatty Acid. Pharmaceutics 2023, 15, 2078. https://doi.org/10.3390/pharmaceutics15082078 |
Resumo(s): | Chronic skin exposure to external hostile agents (e.g., UV radiation, microorganisms, and oxidizing chemicals) may increase oxidative stress, causing skin damage and aging. Because of their well-known skincare and protective benefits, quercetin (Q) and omega-3 fatty acids (ω3) have attracted the attention of the dermocosmetic and pharmaceutical sectors. However, both bioactives have inherent properties that limit their efficient skin delivery. Therefore, nanostructured lipid carriers (NLCs) and enriched PFC® hydrogels (HGs) have been developed as a dual-approach vehicle for Q and/or ω3 skin topical administration to improve bioactives’ stability and skin permeation. Two NLC formulations were prepared with the same lipid composition but differing in surfactant composition (NLC1—soy lecithin and poloxamer 407; NLC2—Tween® 80 and dioctyl sodium sulfosuccinate (DOSS)), which have an impact on physicochemical properties and pharmaceutical and therapeutic performance. Despite both NLCs presenting high Q loading capacity, NLC2′s physicochemical properties make them more suitable for topical skin administration and ensure longer colloidal stability. Additionally, NLC2 demonstrated a more sustained Q release, indicating higher bioactive storage while improving permeability. The occlusive effect of NLCs-enriched HGs also has a positive impact on skin permeability. Q-loaded NLC2, with or without ω3, -enriched HGs demonstrated efficacy as antioxidant and photoprotective formulations as well as effective reduction in S. aureus growth, indicating that they constitute a promising approach for topical skin administration to prevent skin aging and other damaging cutaneous processes. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/86569 |
DOI: | 10.3390/pharmaceutics15082078 |
e-ISSN: | 1999-4923 |
Versão da editora: | https://www.mdpi.com/1999-4923/15/8/2078 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series CBMA - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_56418_1.pdf | 2,79 MB | Adobe PDF | Ver/Abrir |