Development and characterization of nanostructured lipid carriers for cannabidiol delivery

doi:10.1016/j.foodchem.2023.138295

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/89366

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Campo DC	Valor	Idioma
dc.contributor.author	Vardanega, Renata	por
dc.contributor.author	Lüdtke, Fernanda Luisa	por
dc.contributor.author	Loureiro, Luís Carlos Sá	por
dc.contributor.author	Gonçalves, Raquel Filipa Silva	por
dc.contributor.author	Pinheiro, A. C.	por
dc.contributor.author	Vicente, A. A.	por
dc.date.accessioned	2024-03-07T20:13:45Z	-
dc.date.available	2024-03-07T20:13:45Z	-
dc.date.issued	2024-05-30	-
dc.identifier.citation	Vardanega, R., Lüdtke, F. L., Loureiro, L., Gonçalves, R. F. S., Pinheiro, A. C., & Vicente, A. A. (2024, May). Development and characterization of nanostructured lipid carriers for cannabidiol delivery. Food Chemistry. Elsevier BV. http://doi.org/10.1016/j.foodchem.2023.138295	por
dc.identifier.issn	0308-8146	por
dc.identifier.uri	https://hdl.handle.net/1822/89366	-
dc.description	Supplementary data to this article can be found online at https://doi.org/10.1016/j.foodchem.2023.138295.	por
dc.description.abstract	This study evaluated the physicochemical characteristics of nanostructured lipid carriers (NLCs) as a potential vehicle for cannabidiol (CBD), a lipophilic molecule with great potential to promote health benefits. NLCs were produced using hemp seed oil and fully-hydrogenated soybean oil at different proportions. The emulsifiers evaluated were soybean lecithin (SL), Tween 80 (T80) and a mixture of SL:T80 (50:50). CBD was tested in the form of CBD-rich extract or isolate CBD, to verify if it affects the NLCs characteristics. Based on particle size and polydispersity, SL was considered the most suitable emulsifier to produce the NLCs. All lipid proportions evaluated had no remarkable effect on the physicochemical characteristics of NLCs, resulting in CBD-loaded NLCs with particle size below 250 nm, high CBD entrapment efficiency and CBD retention rate of 100% for 30 days, demonstrating that NLCs are a suitable vehicle for both CBD-rich extract or isolate CBD.	por
dc.description.sponsorship	This study received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie SkłodowskaCurie grant agreement No 101062938 and was supported by Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit, and by LABBELS – Associate Laboratory in Biotechnology, Bioengineering and Microelectromechanical Systems, LA/P/0029/2020. Fernanda L. Lüdtke thanks Iceland Liechtenstein Norway Grants (PT-INNOVATION-0105) for the fellowship.	por
dc.language.iso	eng	por
dc.publisher	Elsevier Science BV	por
dc.relation	info:eu-repo/grantAgreement/EC/HE/101062938/EU	por
dc.relation	info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04469%2F2020/PT	por
dc.rights	openAccess	por
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	por
dc.subject	Drug Carriers	por
dc.subject	Health Promotion	por
dc.subject	Soybean Oil	por
dc.subject	Emulsifying Agents	por
dc.subject	Particle Size	por
dc.subject	Polysorbates	por
dc.subject	Nanoparticles	por
dc.subject	Cannabidiol	por
dc.subject	Nanostructures	por
dc.subject	Cannabinoids	por
dc.subject	Emulsifiers	por
dc.subject	Lipid nanoparticles	por
dc.subject	Lipid-based systems	por
dc.subject	Nanoparticles characterization	por
dc.subject	Physical stability	por
dc.title	Development and characterization of nanostructured lipid carriers for cannabidiol delivery	por
dc.type	article	eng
dc.peerreviewed	yes	por
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0308814623029138	por
oaire.citationVolume	441	por
dc.identifier.doi	10.1016/j.foodchem.2023.138295	por
dc.identifier.pmid	38183719	por
sdum.journal	Food Chemistry	por
oaire.version	VoR	por
Aparece nas coleções:	CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series