Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/90073
Título: | Smart mitochondria-specific anchored gold-based nanosystem for integration of tumor imaging and treatment |
Autor(es): | Yin, Xuelian Zhan, Lin Ding, Lin Chen, Xuerui Zhang, Junfeng Li, Chenchen Zhang, Yuxi Khan, Murad Reis, R. L. Wang, Yanli |
Palavras-chave: | Fluorescence imaging Mitochondria-specific anchored Reactive oxygen species Tumor targeting |
Data: | Fev-2023 |
Editora: | Wiley |
Revista: | Advanced Materials Technologies |
Citação: | Yin X. L., Zhan L., Ding L., Chen X. R., Zhang J. F., Li C. C., Zhang Y. X., Khan M., Reis R. L., Wang Y. L. Smart Mitochondria-Specific Anchored Gold-based Nanosystem for Integration of Tumor Imaging and Treatment, Advanced Materials Technologies, 2023, Vol. 8, Issue 10, pp. 2201929, doi:https://doi.org/10.1002/admt.202201929 |
Resumo(s): | Although recent advances have been made in improving the efficacy of photodynamic therapy, efficient therapeutic approaches based on reactive oxygen species (ROS) are needed, particularly mitochondria-specific targeting of nanomaterials that can alter the internal environment of organelles. Herein, we report the facile synthesis of mitochondria-specific anchored nano-complexes (AG-CNP) comprised of a skeleton of gold and carbon atoms for cancer therapy. Compared to the effects of gold nanoclusters (Au NCs), AG-CNP shows enhanced fluorescence imaging effects, which can be used for tumor monitoring. AG-CNP targets the mitochondria and increases ROS damage in cancer cells. After treatment with AG-CNP, the tumor inhibition rate reaches 70.94%, which is 25.98% and 36.91% higher than that of free doxorubicin (DOX) and gemcitabine (Gem), respectively. Studying the mechanism of AG-CNP inhibiting cancer shows that AG-CNP can promote tumor cells to produce excessive ROS by overexpressing P53 and increasing the number of apoptotic cancer cells, which is caused by overexpression of Caspase1 that was closely related to cell apoptosis. AG-CNP is a promising anticancer drug that targets the mitochondria in vivo to trigger excessive ROS production in tumor cells and inhibit tumor growth. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/90073 |
DOI: | 10.1002/admt.202201929 |
ISSN: | 2365-709X |
Versão da editora: | https://onlinelibrary.wiley.com/doi/10.1002/admt.202201929 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21135-adv-materials-technologies-2023-yin-smart-mitochondria‐specific-anchored-gold‐based-nanosystem-integ.pdf | 2,9 MB | Adobe PDF | Ver/Abrir |