Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/20451
Título: | Silk fibroin microparticles as carriers for delivery of human recombinant BMPs: physical characterization and drug release |
Autor(es): | Bessa, Paulo C. Balmayor, Elizabeth Rosado Azevedo, Helena S. Nürnberger, Sylvia Casal, Margarida van Griensven, M. Reis, R. L. Redl, Heinz |
Palavras-chave: | Bone morphogenetic protein Silk fibroin Microparticles Drug delivery MP-2 BMP-9 BMP-14 BMP-2 |
Data: | 2010 |
Editora: | Wiley |
Revista: | Journal of Tissue Engineering and Regenerative Medicine |
Resumo(s): | Bone morphogenetic proteins (BMPs) are cytokines with strong ability to promote new bone formation. Herein, we report the use of silk fibroin microparticles as carriers for the delivery of BMP-2, BMP-9 or BMP-14. BMP-containing fibroin microparticles were prepared by a mild methodology using dropwise addition of ethanol, exhibiting mean diameters of 2.7 ± 0.3 μm. Encapsulation efficiencies varied between 67.9 ± 6.1 % and 97.7 ± 2.0 % depending on the type and the amount of BMP loaded. Release kinetics showed that BMP-2, BMP-9 and BMP-14 were released in two phases profile, with a burst release in the first two days followed by a slower release, for a period of 14 days. The release data were best explained by Korsmeyer’s model and the Fickian model of drug diffusion. Silk fibroin microparticles can offer a promising approach for the sustained delivery of different BMPs in tissue engineering applications. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/20451 |
DOI: | 10.1002/term.245 |
ISSN: | 1932-7005 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |