Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/20719
Título: | Long-term changes in corneal structure and tear inflammatory mediators after orthokeratology and LASIK |
Autor(es): | González-Pérez, Javier Villa-Collar, César González-Méijome, José Manuel Garcia-Porta, Nery Parafita, Manuel A. |
Palavras-chave: | Inflammatory mediators Orthokeratology |
Data: | 2012 |
Editora: | Association for Research in Vision and Ophthalmology (ARVO) |
Revista: | Investigative Ophthalmology & Visual Science |
Citação: | González-Pérez J, Villa-Collar C, González-Méijome JM, Porta NG, Parafita MÁ. Long-term changes in corneal structure and tear inflammatory mediators after orthokeratology and LASIK. Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5301-11. doi: 10.1167/iovs.11-9155. |
Resumo(s): | PURPOSE: To monitor changes in corneal structure and level of inflammatory mediators in tears of myopic patients following orthokeratology (OK) and laser in situ keratomileusis (LASIK). METHODS: Sixty-two myopic subjects were analyzed in this prospective study. Thirty-two had worn Paragon CRT contact lenses and 30 underwent standard LASIK. Thirty-two control subjects were also recruited. Pachometry and corneal topography were performed 12 months after both interventions. Tears were collected and assayed using ELISA for IL-6, IL-8, matrix metalloproteinase-9 (MMP-9), and epidermal growth factor (EGF). RESULTS: Corneal power decreased in the central area and increased in the paracentral area. Simultaneously, there was a central corneal thinning with mid-peripheral thickening for OK. No changes were observed for LASIK. In comparison with controls, IL-6, IL-8, MMP-9, and EGF levels were increased significantly for OK (P < 0.01). Only MMP-9 (P < 0.01) and EGF (P < 0.01) were increased for LASIK. Pro-inflammatory response was found to be associated with the degree of myopia in the OK group. The MMP-9 and EGF upregulation was linked to the presence of iron deposition in both groups, whereas increased levels of EGF were connected with the presence of myopic regression after LASIK. CONCLUSIONS: Both interventions involved important tissue reshaping. The physical presence of a reverse geometry contact lens caused certain markers to change significantly in comparison with no lens wear or LASIK in the long-term response. MMP-9 was significantly higher in tears of subjects presenting iron deposition after OK or LASIK, and EGF levels seemed to play an important role in postoperative refractive outcomes after LASIK. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/20719 |
DOI: | 10.1167/iovs.11-9155 |
ISSN: | 0146-0404 |
Versão da editora: | http://www.iovs.org/cgi/pmidlookup?view=long&pmid=22789928 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDF - OCV - Artigos/Papers (with refereeing) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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5.5.75. GONZALEZ-PEREZ_12_IOVS (Inflammatory Mediators OrtoK and LASIK).pdf | PDF version | 874,79 kB | Adobe PDF | Ver/Abrir |